Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge

Up to 60% of inflammatory bowel disease (IBD) patients experience abdominal pain in their lifetime regardless of disease activity. Pain negatively affects different areas of daily life and particularly impacts the quality of life of IBD patients. This review provides a comprehensive overview of the...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-07, Vol.11 (15), p.4269
Main Authors: Wils, Pauline, Caron, Bénédicte, D'Amico, Ferdinando, Danese, Silvio, Peyrin-Biroulet, Laurent
Format: Article
Language:English
Subjects:
Abdomen
Brain
Chronic illnesses
Clinical medicine
Crohn's disease
Endoscopy
Immune system
Inflammation
Inflammatory bowel disease
Irritable bowel syndrome
Life Sciences
Narcotics
Nervous system
Pain management
Pathophysiology
Patients
Questionnaires
Remission (Medicine)
Review
Tumor necrosis factor-TNF
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Description
Summary:Up to 60% of inflammatory bowel disease (IBD) patients experience abdominal pain in their lifetime regardless of disease activity. Pain negatively affects different areas of daily life and particularly impacts the quality of life of IBD patients. This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients including peripheral sensitization by inflammation, coexistent irritable bowel syndrome, visceral hypersensitivity, alteration of the brain-gut axis, and the multiple factors contributing to pain persistence. Despite the optimal management of intestinal inflammation, chronic abdominal pain can persist, and pharmacological and non-pharmacological approaches are necessary. Integrating psychological support in care models in IBD could decrease disease burden and health care costs. Consequently, a multidisciplinary approach similar to that used for other chronic pain conditions should be recommended.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11154269