Ceramide/Sphingosine 1-Phosphate Axis as a Key Target for Diagnosis and Treatment in Alzheimer's Disease and Other Neurodegenerative Diseases

Alzheimer's disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the hig...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-07, Vol.23 (15), p.8082
Main Authors: Custodia, Antía, Romaus-Sanjurjo, Daniel, Aramburu-Núñez, Marta, Álvarez-Rafael, Diego, Vázquez-Vázquez, Laura, Camino-Castiñeiras, Javier, Leira, Yago, Pías-Peleteiro, Juan Manuel, Aldrey, José Manuel, Sobrino, Tomás, Ouro, Alberto
Format: Article
Language:English
Subjects:
Alzheimer Disease - diagnosis
Alzheimer Disease - metabolism
Alzheimer Disease - therapy
Alzheimer's disease
Biomarkers
Ceramide
Ceramides - metabolism
Dementia disorders
Humans
Kinases
Lipid metabolism
Lipids
Lysophospholipids
Metabolites
Neurodegeneration
Neurodegenerative Diseases - diagnosis
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - therapy
Review
Sphingolipids
Sphingolipids - metabolism
Sphingosine - analogs & derivatives
Sphingosine - metabolism
Sphingosine 1-phosphate
Transcriptomics
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Summary:Alzheimer's disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23158082