Percutaneous Left Atrial Appendage Closure in a Patient with Diffuse Alveolar Hemorrhaging Associated with Anticoagulant Therapy and Atrial Fibrillation

Diffuse alveolar hemorrhaging (DAH) due to oral anticoagulation (OAC) is a life-threatening condition that leads to severe respiratory failure. There is a clinical dilemma in that OAC-induced DAH often forces the discontinuation of OAC therapy and the administration of high-dose corticosteroids, whi...

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Bibliographic Details
Published in:Internal Medicine 2022/07/01, Vol.61(13), pp.2045-2050
Main Authors: Ogoshi, Takaaki, Fukunaga, Masato, Suzuki, Yu, Taura, Yusuke, Yatera, Kazuhiro
Format: Article
Language:English
Subjects:
Alveoli
Anticoagulants
atrial fibrillation
Cardiovascular diseases
Case Report
corticosteroid
Corticosteroids
diffuse alveolar hemorrhaging
Fibrillation
Internal medicine
Occlusion
Patients
percutaneous left atrial appendage closure
respiratory failure
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Summary:Diffuse alveolar hemorrhaging (DAH) due to oral anticoagulation (OAC) is a life-threatening condition that leads to severe respiratory failure. There is a clinical dilemma in that OAC-induced DAH often forces the discontinuation of OAC therapy and the administration of high-dose corticosteroids, which increases the risk of stroke and cardiovascular events. We herein report the first case of OAC-induced DAH and atrial fibrillation (AF) in a patient who completely discontinued OAC therapy and high-dose corticosteroids after experiencing percutaneous left atrial appendage (LAA) occlusion. This case suggests that percutaneous LAA closure may aid in the management of OAC-induced DAH and AF.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8551-21