Renoprotective effect of Caralluma fimbriata against high-fat diet-induced oxidative stress in Wistar rats

The current study was designed to evaluate the renoprotective effect of hydro-alcoholic extract of Caralluma fimbriata (CFE) against high-fat diet-induced oxidative stress in Wistar rats. Male Wistar rats were randomly divided into five groups: control (C), control treated with CFE (C + CFE), high-f...

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Bibliographic Details
Published in:Yàowu shi͡p︡in fenxi 2016-07, Vol.24 (3), p.586-593
Main Authors: Gujjala, Sudhakara, Putakala, Mallaiah, Nukala, Srinivasulu, Bangeppagari, Manjunatha, Ramaswamy, Rajendran, Desireddy, Saralakumari
Format: Article
Language:English
Subjects:
Alcohol
Aluminum
Antidiabetics
antioxidant enzymes
Antioxidants
Body weight
Caralluma fimbriata
Creatinine
Damage prevention
Diabetes
Diet
Enzymes
Fatty acids
Flavonoids
Glutathione
High fat diet
Hyperglycemia
Insulin resistance
Kidneys
Lipid peroxidation
Markers
Metabolism
Metabolites
Metformin
Obesity
Oral administration
Original
Oxidation
Oxidative stress
Peroxidation
Phenols
Phytochemicals
Proteins
Rats
Rodents
Transaminases
Urea
Ureas
Uric acid
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Summary:The current study was designed to evaluate the renoprotective effect of hydro-alcoholic extract of Caralluma fimbriata (CFE) against high-fat diet-induced oxidative stress in Wistar rats. Male Wistar rats were randomly divided into five groups: control (C), control treated with CFE (C + CFE), high-fat diet fed (HFD), high-fat diet fed treated with CFE (HFD + CFE), and high-fat diet fed treated with metformin (HFD + metformin). CFE was orally administered (200 mg/kg body weight) to Groups C + CFE and HFD + CFE rats for 90 days. Renal functional markers such as, urea, uric acid, and creatinine levels in plasma were quantified during the experimental period. At the end of the experimental period, activities of transaminases and oxidative stress markers, i.e., reduced glutathione (GSH), lipid peroxidation, protein oxidation, and activities of antioxidant enzymes were assayed in renal tissue. Coadministration of CFE along with HF-diet in Group HFD + CFE prevented the rise in the levels of plasma urea, uric acid, and creatinine, and elevated activities of renal transaminases with decreased protein content of Group HFD (p 
ISSN:1021-9498
2224-6614
DOI:10.1016/j.jfda.2016.01.013