Outcomes of intracranial germinoma—A retrospective multinational Asian study on effect of clinical presentation and differential treatment strategies

Abstract Background This multinational study was conducted to report clinical presentations and treatment strategies in patients with intracranial germinomas across selected Asian centers, including failure patterns, risk factors, and outcomes. Methods A retrospective data collection and analysis of...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2022-08, Vol.24 (8), p.1389-1399
Main Authors: Koh, Kyung-Nam, Wong, Ru Xin, Lee, Dong-Eun, Han, Jung Woo, Byun, Hwa Kyung, Yoon, Hong In, Kim, Dong-Seok, Lyu, Chuhl Joo, Kang, Hyoung Jin, Hong, Kyung Taek, Lee, Joo Ho, Kim, Il Han, Phi, Ji Hoon, Kim, Seung-Ki, Wong, Tai-Tong, Lee, Hsin-Lun, Lai, I-Chun, Kang, Yu-Mei, Ra, Young-Shin, Ahn, Seung Do, Im, Ho Joon, Looi, Wen Shen, Low, Sharon Yin Yee, Tan, Enrica Ee Kar, Park, Hyun Jin, Shin, Sang Hoon, Fuji, Hiroshi, Suh, Chang-Ok, Chen, Yi-Wei, Kim, Joo-Young
Format: Article
Language:English
Subjects:
Brain Neoplasms - pathology
Clinical Investigations
Germinoma - drug therapy
Germinoma - pathology
Humans
Pineal Gland - pathology
Retrospective Studies
Salvage Therapy
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Summary:Abstract Background This multinational study was conducted to report clinical presentations and treatment strategies in patients with intracranial germinomas across selected Asian centers, including failure patterns, risk factors, and outcomes. Methods A retrospective data collection and analysis of these patients, treated between 1995 and 2015 from eight healthcare institutions across four countries was undertaken. Results From the results, 418 patients were analyzed, with a median follow-up of 8.9 years; 79.9% of the patients were M0, and 87.6% had β-human chorionic gonadotropin values
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noab295