Gamma knife radiosurgery versus transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: a propensity score matching study

Background The optimal locoregional treatment for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) is unclear. This study aimed to investigate the efficacy of Gamma knife radiosurgery (GKR) versus transcatheter arterial chemoembolization (TACE) in HCC patients with PVTT...

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Published in:Hepatology international 2022-08, Vol.16 (4), p.858-867
Main Authors: Su, Ke, Gu, Tao, Xu, Ke, Wang, Jing, Liao, Hongfei, Li, Xueting, Wen, Lianbin, Song, Yanqiong, Zhong, Jiaqi, He, Bingsheng, Liu, Xin, He, Jie, Liu, Yanlin, Li, Qi, Feng, Xunjie, Chen, Siyu, Yang, Binbin, Huang, Weihong, Jin, Hongping, Luo, Xiaotong, Hu, Teng, Chen, Jiali, Wu, Zhenying, Lu, Simin, Zhang, Jianwen, Rao, Mingyue, Xie, Yunchuan, Zhu, Xiaoning, Chen, Lan, Li, Bo, Su, Song, Yang, Xiaoli, Wang, Juan, Zeng, Hao, Wang, Pan, Yan, Min, Chen, Xiaojing, He, Kun, Han, Yunwei
Format: Article
Language:English
Subjects:
Blood clots
Chemoembolization
ChiCTR2100051057
Chinese Clinical Trials Registry
Clinical trials
Colorectal Surgery
Hepatocellular carcinoma
Hepatology
Liver cancer
Matching
Medicine
Medicine & Public Health
Original
Original Article
Patients
Portal vein
Radiology
Radiosurgery
Subgroups
Surgery
Thrombosis
Tumors
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Summary:Background The optimal locoregional treatment for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) is unclear. This study aimed to investigate the efficacy of Gamma knife radiosurgery (GKR) versus transcatheter arterial chemoembolization (TACE) in HCC patients with PVTT. Methods This retrospective study included 544 HCC patients with PVTT (GKR, 202; TACE, 342). Propensity score matching (PSM) analysis identified 171 matched pairs of patients. The primary endpoint was overall survival (OS). Results Before PSM, the GKR group exhibited longer median OS (mOS) than the TACE group (17.2 vs. 8.0 months, p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-022-10339-2