Novel insights on premature progesterone elevation: a mini-review

In vitro fertilization (IVF) success involves ovarian stimulation with conventional or mild stimulation protocols aimed to yield an adequate number of mature oocytes. These oocytes can be further fertilized and generate good quality embryos to be transferred, ideally in the same cycle. Since 2013, f...

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Bibliographic Details
Published in:JBRA assisted reproduction 2022-01, Vol.26 (3), p.531-537
Main Authors: Cortés-Vazquez, Alfredo, Escobosa, Cristabel, Cortés-Algara, Alfredo L, Moreno-García, Jesús D
Format: Article
Language:English
Subjects:
Androgens
Dehydrogenases
Embryos
Estrogens
In vitro fertilization
Menstruation
Metabolites
Ovaries
Ovulation
Patients
Pharmacokinetics
Review
Steroids
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Summary:In vitro fertilization (IVF) success involves ovarian stimulation with conventional or mild stimulation protocols aimed to yield an adequate number of mature oocytes. These oocytes can be further fertilized and generate good quality embryos to be transferred, ideally in the same cycle. Since 2013, following the results of a meta-analysis including more than 60,000 IVF cycles, the negative effects of premature progesterone elevation on reproductive outcomes have been demonstrated. Nowadays, evidence is emerging on the limited regulation on serum progesterone values, demonstrating significantly lower live birth rates in patients with either low (
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20210096