miR‐3184‐3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2‐like macrophage polarization

Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this stu...

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Bibliographic Details
Published in:Cancer science 2022-08, Vol.113 (8), p.2668-2680
Main Authors: Xu, Hao, Li, Ming, Pan, Ziwen, Zhang, Zongpu, Gao, Zijie, Zhao, Rongrong, Li, Boyan, Qi, Yanhua, Qiu, Wei, Guo, Qindong, Zhang, Shouji, Fan, Yang, Zhao, Shulin, Wang, Shaobo, Guo, Xing, Deng, Lin, Xue, Hao, Li, Gang
Format: Article
Language:English
Subjects:
Apoptosis
Biopsy
Brain cancer
Cell culture
Cerebrospinal fluid
Diagnosis
Exosomes
Flow cytometry
Gene expression
Genotype & phenotype
Glioma
gliomas
Growth factors
Laboratory animals
Leukocyte migration
macrophage
Macrophages
MicroRNAs
miRNA
Original
ORIGINAL ARTICLES
Phenotypes
Proteins
Software
tumor immune microenvironment
Tumors
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Summary:Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future. MiR‐3184‐3p was enriched in cerebrospinal fluid exosomes in glioma patients. MiR‐3184 promotes proliferation, migration, and invasion in glioma. MiR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.15372