Experimental evaluation of absolute quantification in 99mTc‐TRODAT‐1 SPECT/CT brain dopamine transporter (DAT) studies

Objective To evaluate the quantitative accuracy of clinical brain dopamine transporters (DAT) investigations utilizing 99mTc‐TRODAT‐1 single‐photon emission computed tomography (SPECT)/computed tomography (CT) in experimental and clinical settings. Materials and methods The study used an experimenta...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied clinical medical physics 2022-08, Vol.23 (8), p.n/a
Main Authors: Zainudin, Norasma Amira, Zulkifli, Nadiah, Hamid, Khadijah, Hashim, Hazlin, Mansor, Syahir
Format: Article
Language:English
Subjects:
99mTc‐TRODAT‐1
Brain research
DAT
Datasets
Dopamine
Magnetic resonance imaging
Medical Imaging
quantification
SPECT/CT
SUVr
Taguchi methods
Tomography
Variance analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To evaluate the quantitative accuracy of clinical brain dopamine transporters (DAT) investigations utilizing 99mTc‐TRODAT‐1 single‐photon emission computed tomography (SPECT)/computed tomography (CT) in experimental and clinical settings. Materials and methods The study used an experimental phantom evaluation and a clinical dataset. Three‐dimensional‐ordered subsets expectation–maximization reconstructed the original and resampled datasets using attenuation correction, scatter correction, and resolution recovery. The reconstructed data were analyzed and reported as percentage difference, standardized uptake value reference (SUVr), and a coefficient of variation (CoV). The Taguchi method tested the impact of the three different parameters on signal‐to‐noise ratio (SNR) and SUVr, including number iteration, Poisson resampling, and phantom setup, with and without the plaster of Paris (POP). Six 99mTc‐TRODAT‐1 SPECT/CT scans were acquired in healthy subjects for verification purposes. Results The percentage activity difference between the phantom with and without POP is 20% and 5%, respectively. The SUVr reveals a 10% underestimate for both with and without POP. When it comes to the influence of Poisson resampling, the SUVr value for 75% Poisson resampling indicates 10% underestimation on both sides of the caudate and putamen area, with and without POP. When 25% of Poisson resampling is applied, the SUVr value is overestimated (±35%). In the Taguchi analysis, iteration numbers were the most dominant factor with the F‐value of 9.41 and the contribution rate of 52.66% (p 
ISSN:1526-9914
1526-9914
DOI:10.1002/acm2.13723