Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chloro­phen­yl)-3-{[(4-chloro­phen­yl)formamido]­imino}-7-methyl-2H,3H,5H-[1,3]thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate

• Published in: Acta crystallographica. Section E, Crystallographic communications Crystallographic communications, 2022-07, Vol.78 (Pt 8), p.846-850
• Main Authors: Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Alfayomy, Abdallah M., Seri, Sahar M. Abou, Abdel-Raheem, Shaban A. A., Ul-Malik, Mokhtar A. Abd
• Format: Article
• Language: English
• Subjects: Research Communications
• ISSN: 2056-9890
• DOI: 10.1107/S205698902200603X

The thia­zole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation In the crystal, N—H⋯N plus C—H⋯N hydrogen bonds form helical chains along the b -axis direction, which are linked into thick sheets parallel to the bc plane by C—H⋯O hydrogen bonds and π–π inter­actions between the formamido carbonyl groups and the thia­zole rings. In the title mol­ecule, C 23 H 20 Cl 2 N 4 O 3 S, the thia­zole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the crystal, thick sheets parallel to the bc plane are formed by N—H⋯N, C—H⋯N and C—H⋯O hydrogen bonds together with π–π inter­actions between the formamido carbonyl groups and the thia­zole rings. Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H⋯H (30.9%), Cl⋯H/H⋯Cl (20.7%), C⋯H/H⋯C (16.8%) and O⋯H/H⋯O (11.4%) inter­actions.