Temporal analysis of Lassa virus infection and transmission in experimentally infected Mastomys natalensis

Little is known about the temporal patterns of infection and transmission of Lassa virus (LASV) within its natural reservoir ( ). Here, we characterize infection dynamics and transmissibility of a LASV isolate (Soromba-R) in adult lab-reared originating from Mali. The lab-reared M. proved to be high...

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Bibliographic Details
Published in:PNAS nexus 2022-07, Vol.1 (3), p.pgac114-pgac114
Main Authors: Safronetz, David, Rosenke, Kyle, Meade-White, Kimberley, Sloan, Angela, Maiga, Ousmane, Bane, Sidy, Martellaro, Cynthia, Scott, Dana P, Sogoba, Nafomon, Feldmann, Heinz
Format: Article
Language:English
Subjects:
Biological, Health, and Medical Sciences
Development and progression
Distribution
Genetic aspects
Health aspects
Lassa fever
Muridae
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Summary:Little is known about the temporal patterns of infection and transmission of Lassa virus (LASV) within its natural reservoir ( ). Here, we characterize infection dynamics and transmissibility of a LASV isolate (Soromba-R) in adult lab-reared originating from Mali. The lab-reared M. proved to be highly susceptible to LASV isolates from geographically distinct regions of West Africa via multiple routes of exposure, with 50% infectious doses of 
ISSN:2752-6542
2752-6542
DOI:10.1093/pnasnexus/pgac114