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Evaluation of placental growth potential and placental bed perfusion by 3D ultrasound for early second-trimester prediction of preeclampsia

Purpose This study aimed to investigate whether placental parameters measured by three-dimensional ultrasound are associated with preeclampsia (PE) and small-for-gestational-age (SGA). Methods In total, 1163 pregnancies at 11–14 weeks of gestation were recruited between October 8, 2020, and April 30...

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Published in:Journal of assisted reproduction and genetics 2022-07, Vol.39 (7), p.1545-1554
Main Authors: Cui, Hong, Yu, Leilei, Li, Hua, Wang, Hongling, Liang, Wenwen, Wang, Huige, Wang, Huifeng
Format: Article
Language:English
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Summary:Purpose This study aimed to investigate whether placental parameters measured by three-dimensional ultrasound are associated with preeclampsia (PE) and small-for-gestational-age (SGA). Methods In total, 1163 pregnancies at 11–14 weeks of gestation were recruited between October 8, 2020, and April 30, 2021. Placenta volume (PV), placental bed vascularization flow index (PBVFI), and uterine arteries pulse index (UtA-PI) were measured. Placental quotient (PQ = PV/weeks of gestation) was calculated. All participants were re-examined 4 weeks later. The placental volume growth rate (PVGR = placental volume difference between the two examinations/interval days) was also calculated. Patients were divided into four groups by the gestational age at the onset of PE and birth weight: early-onset PE (E-PE, n  = 18), late-onset PE (L-PE, n  = 36), isolated SGA5 (birth weight less than the fifth percentile for gestational age without PE, n  = 9), and unaffected ( n  = 1100) groups. Results A predictive model for E-PE was established, which consisted of unnatural conception, chronic hypertension, PBVFI (of second examination), and PVGR for E-PE; 94.4% sensitivity and 96.7% specificity by receiver operating characteristic curve analysis. Conclusions Overall, decreased placental growth potential and low placental bed perfusion in the early second trimester have potential in predicting E-PE.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-022-02530-z