Activation Markers on B and T Cells and Immune Checkpoints in Autoimmune Rheumatic Diseases

In addition to identifying the major B- and T-cell subpopulations involved in autoimmune rheumatic diseases (ARDs), in recent years special attention has been paid to studying the expression of their activation markers and immune checkpoints (ICPs). The activation markers on B and T cells are a cons...

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Published in:International journal of molecular sciences 2022-08, Vol.23 (15), p.8656
Main Authors: Gerasimova, Elena V., Tabakov, Dmitry V., Gerasimova, Daria A., Popkova, Tatiana V.
Format: Article
Language:English
Subjects:
Adapter proteins
Antigens
Apoptosis
Cytokines
Growth factors
Immune checkpoint
Immune system
Immunotherapy
Inflammation
Kinases
Ligands
Lymphocytes
Lymphocytes T
Markers
Medical prognosis
Mutation
Pathogenesis
Regulation
Review
Rheumatic diseases
Roles
Tumor necrosis factor-TNF
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container_title International journal of molecular sciences
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creator Gerasimova, Elena V.
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description In addition to identifying the major B- and T-cell subpopulations involved in autoimmune rheumatic diseases (ARDs), in recent years special attention has been paid to studying the expression of their activation markers and immune checkpoints (ICPs). The activation markers on B and T cells are a consequence of the immune response, and these molecules are considered as sensitive specific markers of ARD activity and as promising targets for immunotherapy. ICPs regulate the activation of the immune response by preventing the initiation of autoimmune processes, and they modulate it by reducing immune cell-induced organ and tissue damage. The article considers the possible correlation of ICPs with the activity of ARDs, the efficacy of specific ARD treatments, and the prospects for the use of activation molecules and activation/blocking ICPs for the treatment of ARDs.
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subjects Adapter proteins
Antigens
Apoptosis
Cytokines
Growth factors
Immune checkpoint
Immune system
Immunotherapy
Inflammation
Kinases
Ligands
Lymphocytes
Lymphocytes T
Markers
Medical prognosis
Mutation
Pathogenesis
Regulation
Review
Rheumatic diseases
Roles
Tumor necrosis factor-TNF
title Activation Markers on B and T Cells and Immune Checkpoints in Autoimmune Rheumatic Diseases
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