Pharmacological Effect of Panax notoginseng Saponins on Cerebral Ischemia in Animal Models

Panax notoginseng saponins (PNS), bioactive compounds, are commonly used to treat ischemic heart and cerebral diseases in China and other Asian countries. Most previous studies of PNS have focused on the mechanisms underlying their treatment of ischemic cardiovascular diseases but not cerebral ische...

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Bibliographic Details
Published in:BioMed research international 2022-08, Vol.2022, p.1-12
Main Authors: Dong, Chao, Li, Jiawei, Zhao, Ming, Chen, Lin, Zhai, Xiaochen, Song, Lingling, Zhao, Jin, Sun, Qiang, Wu, Jie, Xie, Xiaolu
Format: Article
Language:English
Subjects:
Animal models
Arteries
Bioactive compounds
Blood flow
Brain
Calcium (intracellular)
Calcium ions
Cardiovascular diseases
Care and treatment
Carotid arteries
Carotid artery
Cerebral blood flow
Cerebral ischemia
Chemical properties
Collagen
Composition
Coronary artery disease
Drug dosages
Energy metabolism
Epinephrine
Glucose
Health aspects
Heart diseases
Hemiplegia
Hypoxia
Ischemia
Jugular vein
Laboratory animals
Neurological diseases
Notoginseng
Occlusion
Panax notoginseng
Pharmaceuticals
Pharmacology
Rats
Rodents
Saponins
Surgery
Testing
Thromboembolism
Thrombolysis
Thrombosis
Veins
Veins & arteries
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Summary:Panax notoginseng saponins (PNS), bioactive compounds, are commonly used to treat ischemic heart and cerebral diseases in China and other Asian countries. Most previous studies of PNS have focused on the mechanisms underlying their treatment of ischemic cardiovascular diseases but not cerebral ischemic diseases. This study sought to explore the pharmacological mechanisms underlying the effectiveness of PNS in treating cerebral ischemic diseases. Different experimental cerebral ischemia models (including middle cerebral artery occlusion (MCAO) and the blockade of four arteries in rats, collagen-adrenaline-induced systemic intravascular thrombosis in mice, thrombosis of carotid artery-jugular vein blood flow in the bypass of rats, and hypoxia tolerance in mice) were used to investigate the mechanisms underlying the actions of PNS on cerebral ischemia. The results indicated that (1) PNS improved neurological function and reduced the cerebral ischemia infraction area in MCAO rats; (2) PNS improved motor coordination function in rats with complete cerebral ischemia (blockade of four arteries), decreased Ca2+ levels, and ameliorated energy metabolism in the brains of ischemia rats; (3) PNS reduced thrombosis in common carotid artery-jugular vein blood flow in the bypass of rats; (4) PNS provided significant promise in antistroke hemiplegia and hypoxia tolerance in mice. In conclusion, PNS showed antagonistic effects on ischemic stroke, and pharmacological mechanisms are likely to be associated with the reduction of cerebral pathological damage, thrombolysis, antihypoxia, and improvement in the intracellular Ca2+ overload and cerebral energy metabolism.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/4281483