Role of Ubiquilin-2 in Proteostasis and Tau Aggregation in Tauopathies

Xia discusses the role of ubiquilin-2 (UBQLN2) in proteostasis and tau aggregation in tauopathies, a group of neurologic disorders. UBQLN2 contributes to both the ubiquitin-proteasome system and the autophagy-lysosome system. Specifically, UBQLN2 helps shuttle ubiquitin-tagged, misfolded, or nonfunc...

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Bibliographic Details
Published in:The Journal of neuroscience 2022-08, Vol.42 (32), p.6168-6170
Main Author: Xia, Yuxing
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Agglomeration
Autophagy
Autophagy-Related Proteins - metabolism
Degradation
Humans
Journal Club
Neurodegenerative diseases
Proteasomes
Proteostasis
Tau protein
tau Proteins - metabolism
Tauopathies - metabolism
Transcription Factors - metabolism
Ubiquitin
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Summary:Xia discusses the role of ubiquilin-2 (UBQLN2) in proteostasis and tau aggregation in tauopathies, a group of neurologic disorders. UBQLN2 contributes to both the ubiquitin-proteasome system and the autophagy-lysosome system. Specifically, UBQLN2 helps shuttle ubiquitin-tagged, misfolded, or nonfunctional proteins to the proteasome for degradation. In HEK293 cells, coexpression of wild-type tau and UBQLN2 led to increased tau degradation and decreased tau levels.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.0839-22.2022