Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain

Objective:  To evaluate the efficacy of periapical infiltration injection of dexamethasone and morphine in reducing postoperative endodontic pain. Method:  Ninety patients participated in this double‐blind randomised controlled clinical trial. They were referred to the dental school of Shahid Behesh...

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Bibliographic Details
Published in:International dental journal 2012-04, Vol.62 (2), p.74-78
Main Authors: Shantiaee, Yazdan, Mahjour, Faranak, Dianat, Omid
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analgesics, Opioid - administration & dosage
Anti-Inflammatory Agents - administration & dosage
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dexamethasone
Dexamethasone - administration & dosage
Double-Blind Method
endodontic
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Follow-Up Studies
Glucocorticoids - administration & dosage
Humans
Injections
Male
Medical sciences
Molar - pathology
morphine
Morphine - administration & dosage
Non tumoral diseases
Original
Otorhinolaryngology. Stomatology
Pain
Pain Measurement
Pain, Postoperative - prevention & control
periapical infiltration injection
Periapical Tissue
Pharmacology. Drug treatments
Placebos
postoperative pain
Root Canal Preparation - methods
Root Canal Therapy - methods
Young Adult
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Summary:Objective:  To evaluate the efficacy of periapical infiltration injection of dexamethasone and morphine in reducing postoperative endodontic pain. Method:  Ninety patients participated in this double‐blind randomised controlled clinical trial. They were referred to the dental school of Shahid Beheshti Medical University, Tehran, Iran for conventional endodontic treatment of molar teeth. The canals of each tooth were completely prepared with cleansing and shaping. The patients were randomly divided into three experimental groups to receive dexamethasone, morphine or normal saline (1 mL). Patients were then instructed to complete a pain diary 4, 8, 24 and 48 h after the appointment. Statistical analysis consisted of chi‐squared test, analysis of variance and Kruskal–Wallis test. Results:  There was a statistically significant correlation between dexamethasone or morphine treatment and decreased levels and incidence of endodontic pain at 4, 8 and 24 h, but not at 48 h (P 
ISSN:0020-6539
1875-595X
DOI:10.1111/j.1875-595X.2011.00092.x