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Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment
Objective To assess the ability of various fluoride salts to protect enamel against acid attack via a barrier mechanism. Methods Extracted human enamel specimens were cleaned and rinsed, then soaked in pooled human saliva for 1 hour to initiate formation of an early pellicle. Groups of three specime...
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| Published in: | International dental journal 2014-03, Vol.64 (s1), p.16-21 |
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| container_title | International dental journal |
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| creator | Faller, Robert V. Eversole, Sandra L. |
| description | Objective
To assess the ability of various fluoride salts to protect enamel against acid attack via a barrier mechanism.
Methods
Extracted human enamel specimens were cleaned and rinsed, then soaked in pooled human saliva for 1 hour to initiate formation of an early pellicle. Groups of three specimens each were etched for 10 minutes in 1% citric acid (pH 2.3), treated in a 1:3 slurry of dentifrice [1,100 ppm F as stannous fluoride (SnF2), 1,100 ppm F as sodium fluoride (NaF), 1,000 ppm F as sodium monofluorophosphate (SMFP), or 1,400 ppm F as amine fluoride (AmF)] and saliva for 2 minutes, exposed to 2% alizarin red‐S (a calcium‐selective dye) and rinsed again. The relative ability of each test product to deposit a barrier layer on the enamel surface was measured by its ability to protect against attachment of the calcium‐selective dye.
Results
Specimens treated with the SnF2 dentifrice showed the least dye attachment, indicating a high level of surface protection. On a five‐point scale, with 0 being no dye deposition (100% protection) and four being complete dye coverage (0% protection), the SnF2‐treated specimens scored an average of 0.25, with NaF scoring 3.4, SMFP scoring 3.4 and AmF scoring 3.7. Protection of the enamel surface was significantly higher for the SnF2 product than for the other products (P |
| doi_str_mv | 10.1111/idj.12098 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9376556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3224872251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4818-b2f14fb685b2848fa1cfe4ac3860e78cc29ddae727400c823b2f75cccfd02eba3</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EokvhwBdAkbjAIduxHcfOBakU2gYtUImicrMcZ8x6yZ9iZwv77fGy7QqQ8MG2NL_3ZkaPkKcU5jSdI9-u5pRBpe6RGVVS5KISX-6TGQCDvBS8OiCPYlwBFIpD-ZAcsEJIKgFmZHERxgnt5G8wQ-fSL2ajyz4NpyzLswsTpqyu63n2Hu3SDD7222pjQvAYss5s0m2mydhlj8P0mDxwpov45PY9JJ9P316enOeLj2f1yfEit4WiKm-Yo4VrSiUapgrlDLUOC2O5KgGlspZVbWtQMlkAWMV4EkhhrXUtMGwMPySvdr7X66bH1qbWwXT6OvjehI0ejdd_Vwa_1F_HG11xWQpRJoMXtwZh_L7GOOneR4tdZwYc11FTAVwUjFc8oc__QVfjOgxpvS0FEoQAmqiXO8qGMcaAbj8MBb3NSKeM9O-MEvvsz-n35F0oCTjaAT98h5v_O-n6zbs7y3yn8HHCn3uFCd90KbkU-urDmU47leeLyyv9mv8CgESptg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1500705501</pqid></control><display><type>article</type><title>Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment</title><source>ScienceDirect®</source><source>PubMed Central</source><creator>Faller, Robert V. ; Eversole, Sandra L.</creator><creatorcontrib>Faller, Robert V. ; Eversole, Sandra L.</creatorcontrib><description>Objective
To assess the ability of various fluoride salts to protect enamel against acid attack via a barrier mechanism.
Methods
Extracted human enamel specimens were cleaned and rinsed, then soaked in pooled human saliva for 1 hour to initiate formation of an early pellicle. Groups of three specimens each were etched for 10 minutes in 1% citric acid (pH 2.3), treated in a 1:3 slurry of dentifrice [1,100 ppm F as stannous fluoride (SnF2), 1,100 ppm F as sodium fluoride (NaF), 1,000 ppm F as sodium monofluorophosphate (SMFP), or 1,400 ppm F as amine fluoride (AmF)] and saliva for 2 minutes, exposed to 2% alizarin red‐S (a calcium‐selective dye) and rinsed again. The relative ability of each test product to deposit a barrier layer on the enamel surface was measured by its ability to protect against attachment of the calcium‐selective dye.
Results
Specimens treated with the SnF2 dentifrice showed the least dye attachment, indicating a high level of surface protection. On a five‐point scale, with 0 being no dye deposition (100% protection) and four being complete dye coverage (0% protection), the SnF2‐treated specimens scored an average of 0.25, with NaF scoring 3.4, SMFP scoring 3.4 and AmF scoring 3.7. Protection of the enamel surface was significantly higher for the SnF2 product than for the other products (P < 0.05), with no significant differences among the other three F salts.
Conclusions
These results demonstrate that after an aggressive acid challenge, SnF2 deposits a barrier layer onto the pellicle‐coated enamel surface, and the barrier layer which attaches onto acid challenged tooth surfaces is different from any that might be provided by treatment with the other fluoride compounds tested.</description><identifier>ISSN: 0020-6539</identifier><identifier>EISSN: 1875-595X</identifier><identifier>DOI: 10.1111/idj.12098</identifier><identifier>PMID: 24571700</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Anthraquinones ; Citric Acid - adverse effects ; Coloring Agents ; Dental Enamel - drug effects ; Dental Pellicle - drug effects ; Dentifrices - therapeutic use ; Dentistry ; Diamines - therapeutic use ; Enamel ; Erosion ; fluoride ; Fluorides ; Fluorides - therapeutic use ; Humans ; Hydrogen-Ion Concentration ; Original ; Phosphates - therapeutic use ; Protective Agents - therapeutic use ; Saliva - physiology ; Silicic Acid - therapeutic use ; Sodium Fluoride - therapeutic use ; stannous fluoride ; Tin Fluorides - therapeutic use ; Tooth Erosion - prevention & control ; toothpaste ; Toothpastes - therapeutic use ; toothwear</subject><ispartof>International dental journal, 2014-03, Vol.64 (s1), p.16-21</ispartof><rights>2014 FDI World Dental Federation</rights><rights>2014 FDI World Dental Federation.</rights><rights>Copyright © 2014 FDI World Dental Federation</rights><rights>Copyright © 2014 FDI World Dental Federation. Published by Elsevier Inc. 2014 FDI World Dental Federation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4818-b2f14fb685b2848fa1cfe4ac3860e78cc29ddae727400c823b2f75cccfd02eba3</citedby><cites>FETCH-LOGICAL-c4818-b2f14fb685b2848fa1cfe4ac3860e78cc29ddae727400c823b2f75cccfd02eba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376556/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376556/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24571700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faller, Robert V.</creatorcontrib><creatorcontrib>Eversole, Sandra L.</creatorcontrib><title>Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment</title><title>International dental journal</title><addtitle>Int Dent J</addtitle><description>Objective
To assess the ability of various fluoride salts to protect enamel against acid attack via a barrier mechanism.
Methods
Extracted human enamel specimens were cleaned and rinsed, then soaked in pooled human saliva for 1 hour to initiate formation of an early pellicle. Groups of three specimens each were etched for 10 minutes in 1% citric acid (pH 2.3), treated in a 1:3 slurry of dentifrice [1,100 ppm F as stannous fluoride (SnF2), 1,100 ppm F as sodium fluoride (NaF), 1,000 ppm F as sodium monofluorophosphate (SMFP), or 1,400 ppm F as amine fluoride (AmF)] and saliva for 2 minutes, exposed to 2% alizarin red‐S (a calcium‐selective dye) and rinsed again. The relative ability of each test product to deposit a barrier layer on the enamel surface was measured by its ability to protect against attachment of the calcium‐selective dye.
Results
Specimens treated with the SnF2 dentifrice showed the least dye attachment, indicating a high level of surface protection. On a five‐point scale, with 0 being no dye deposition (100% protection) and four being complete dye coverage (0% protection), the SnF2‐treated specimens scored an average of 0.25, with NaF scoring 3.4, SMFP scoring 3.4 and AmF scoring 3.7. Protection of the enamel surface was significantly higher for the SnF2 product than for the other products (P < 0.05), with no significant differences among the other three F salts.
Conclusions
These results demonstrate that after an aggressive acid challenge, SnF2 deposits a barrier layer onto the pellicle‐coated enamel surface, and the barrier layer which attaches onto acid challenged tooth surfaces is different from any that might be provided by treatment with the other fluoride compounds tested.</description><subject>Anthraquinones</subject><subject>Citric Acid - adverse effects</subject><subject>Coloring Agents</subject><subject>Dental Enamel - drug effects</subject><subject>Dental Pellicle - drug effects</subject><subject>Dentifrices - therapeutic use</subject><subject>Dentistry</subject><subject>Diamines - therapeutic use</subject><subject>Enamel</subject><subject>Erosion</subject><subject>fluoride</subject><subject>Fluorides</subject><subject>Fluorides - therapeutic use</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Original</subject><subject>Phosphates - therapeutic use</subject><subject>Protective Agents - therapeutic use</subject><subject>Saliva - physiology</subject><subject>Silicic Acid - therapeutic use</subject><subject>Sodium Fluoride - therapeutic use</subject><subject>stannous fluoride</subject><subject>Tin Fluorides - therapeutic use</subject><subject>Tooth Erosion - prevention & control</subject><subject>toothpaste</subject><subject>Toothpastes - therapeutic use</subject><subject>toothwear</subject><issn>0020-6539</issn><issn>1875-595X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kU9v1DAQxS0EokvhwBdAkbjAIduxHcfOBakU2gYtUImicrMcZ8x6yZ9iZwv77fGy7QqQ8MG2NL_3ZkaPkKcU5jSdI9-u5pRBpe6RGVVS5KISX-6TGQCDvBS8OiCPYlwBFIpD-ZAcsEJIKgFmZHERxgnt5G8wQ-fSL2ajyz4NpyzLswsTpqyu63n2Hu3SDD7222pjQvAYss5s0m2mydhlj8P0mDxwpov45PY9JJ9P316enOeLj2f1yfEit4WiKm-Yo4VrSiUapgrlDLUOC2O5KgGlspZVbWtQMlkAWMV4EkhhrXUtMGwMPySvdr7X66bH1qbWwXT6OvjehI0ejdd_Vwa_1F_HG11xWQpRJoMXtwZh_L7GOOneR4tdZwYc11FTAVwUjFc8oc__QVfjOgxpvS0FEoQAmqiXO8qGMcaAbj8MBb3NSKeM9O-MEvvsz-n35F0oCTjaAT98h5v_O-n6zbs7y3yn8HHCn3uFCd90KbkU-urDmU47leeLyyv9mv8CgESptg</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Faller, Robert V.</creator><creator>Eversole, Sandra L.</creator><general>Blackwell Publishing Ltd</general><general>Elsevier Limited</general><general>Elsevier</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment</title><author>Faller, Robert V. ; Eversole, Sandra L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4818-b2f14fb685b2848fa1cfe4ac3860e78cc29ddae727400c823b2f75cccfd02eba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anthraquinones</topic><topic>Citric Acid - adverse effects</topic><topic>Coloring Agents</topic><topic>Dental Enamel - drug effects</topic><topic>Dental Pellicle - drug effects</topic><topic>Dentifrices - therapeutic use</topic><topic>Dentistry</topic><topic>Diamines - therapeutic use</topic><topic>Enamel</topic><topic>Erosion</topic><topic>fluoride</topic><topic>Fluorides</topic><topic>Fluorides - therapeutic use</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Original</topic><topic>Phosphates - therapeutic use</topic><topic>Protective Agents - therapeutic use</topic><topic>Saliva - physiology</topic><topic>Silicic Acid - therapeutic use</topic><topic>Sodium Fluoride - therapeutic use</topic><topic>stannous fluoride</topic><topic>Tin Fluorides - therapeutic use</topic><topic>Tooth Erosion - prevention & control</topic><topic>toothpaste</topic><topic>Toothpastes - therapeutic use</topic><topic>toothwear</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faller, Robert V.</creatorcontrib><creatorcontrib>Eversole, Sandra L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International dental journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faller, Robert V.</au><au>Eversole, Sandra L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment</atitle><jtitle>International dental journal</jtitle><addtitle>Int Dent J</addtitle><date>2014-03</date><risdate>2014</risdate><volume>64</volume><issue>s1</issue><spage>16</spage><epage>21</epage><pages>16-21</pages><issn>0020-6539</issn><eissn>1875-595X</eissn><abstract>Objective
To assess the ability of various fluoride salts to protect enamel against acid attack via a barrier mechanism.
Methods
Extracted human enamel specimens were cleaned and rinsed, then soaked in pooled human saliva for 1 hour to initiate formation of an early pellicle. Groups of three specimens each were etched for 10 minutes in 1% citric acid (pH 2.3), treated in a 1:3 slurry of dentifrice [1,100 ppm F as stannous fluoride (SnF2), 1,100 ppm F as sodium fluoride (NaF), 1,000 ppm F as sodium monofluorophosphate (SMFP), or 1,400 ppm F as amine fluoride (AmF)] and saliva for 2 minutes, exposed to 2% alizarin red‐S (a calcium‐selective dye) and rinsed again. The relative ability of each test product to deposit a barrier layer on the enamel surface was measured by its ability to protect against attachment of the calcium‐selective dye.
Results
Specimens treated with the SnF2 dentifrice showed the least dye attachment, indicating a high level of surface protection. On a five‐point scale, with 0 being no dye deposition (100% protection) and four being complete dye coverage (0% protection), the SnF2‐treated specimens scored an average of 0.25, with NaF scoring 3.4, SMFP scoring 3.4 and AmF scoring 3.7. Protection of the enamel surface was significantly higher for the SnF2 product than for the other products (P < 0.05), with no significant differences among the other three F salts.
Conclusions
These results demonstrate that after an aggressive acid challenge, SnF2 deposits a barrier layer onto the pellicle‐coated enamel surface, and the barrier layer which attaches onto acid challenged tooth surfaces is different from any that might be provided by treatment with the other fluoride compounds tested.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24571700</pmid><doi>10.1111/idj.12098</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International dental journal, 2014-03, Vol.64 (s1), p.16-21 |
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| source | ScienceDirect®; PubMed Central |
| subjects | Anthraquinones Citric Acid - adverse effects Coloring Agents Dental Enamel - drug effects Dental Pellicle - drug effects Dentifrices - therapeutic use Dentistry Diamines - therapeutic use Enamel Erosion fluoride Fluorides Fluorides - therapeutic use Humans Hydrogen-Ion Concentration Original Phosphates - therapeutic use Protective Agents - therapeutic use Saliva - physiology Silicic Acid - therapeutic use Sodium Fluoride - therapeutic use stannous fluoride Tin Fluorides - therapeutic use Tooth Erosion - prevention & control toothpaste Toothpastes - therapeutic use toothwear |
| title | Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment |
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