SARS-CoV-2 Seroprevalence: Demographic and Behavioral Factors Associated With Seropositivity Among College Students in a University Setting

• Published in: Journal of adolescent health 2022-11, Vol.71 (5), p.559-569
• Main Authors: Diepstra, Karen, Bullington, Brooke W., Premkumar, Lakshmanane, Shook-Sa, Bonnie E., Jones, Corbin, Pettifor, Audrey
• Format: Article
• Language: English
• Subjects: Campus life; College life; COVID-19; Demography; Humans; Original; SARS-CoV-2; Seroepidemiologic Studies; Serology; Seroprevalence; Students; Universities
• ISSN: 1054-139X; 1879-1972; 1879-1972
• DOI: 10.1016/j.jadohealth.2022.06.015

Examine SARS-CoV-2 seroprevalence and the association of seropositivity with demographic, geographic, and behavioral variables among University of North Carolina Chapel Hill (UNC-CH) undergraduate students enrolled in the fall 2020 semester. All UNC-CH undergraduate students were invited to participate in the Heelcheck study; participants were weighted to the UNC-CH undergraduate population using raking methods. We estimate SARS-CoV-2 seroprevalence at study entrance (11/12/2020–12/10/2020) and bivariable associations using log-binomial regression. SARS-CoV-2 seroprevalence was 7.3% (95% confidence interval (CI): 5.4%–9.2%) at baseline. Compared to students who were living off-campus in the Chapel Hill/Carrboro area (CH) for the Fall 2020 semester (8.6% seroprevalence), students who never returned to CH had lower seroprevalence (1.9%, prevalence ratio (PR), 95% CI: 0.22, 0.06–0.81), whereas, students who started the semester on-campus and moved to off-campus CH housing had 18.9% seroprevalence (PR, 95% CI: 2.21, 1.04–4.72) and students who spent the semester living in a Sorority/Fraternity house had 46.8% seroprevalence (PR, 95% CI: 5.47, 2.62–11.46). Those who predicted they would join an indoor party unmasked had 3.8 times the seroprevalence of those who indicated they would not attend (PR, 95% CI: 3.80, 1.58–9.16). Compared to students who disagreed with the statement “…I am not going to let COVID-19 stop me from having fun…”, those who agreed had higher seroprevalence (14.0% vs. 5.7%; (PR, 95% CI: 2.45, 1.13–5.32)). Increased seroprevalence was associated with congregate living and participation (actual or endorsed) in social activities. During pandemics, universities must create safe socializing opportunities while minimizing transmission.