Predictive Value of HPV E6/E7 mRNA Detection on the Outcome of Cervical LSIL

Objective. To assess the predictive worth of HPV E6/E7 mRNA detection in the outcome of the cervical low-grade squamous intraepithelial lesion (LSIL). From September 2017 to early September 2019, patients screened for high-risk HPV positive or abnormal cervical liquid-based cytology were retrospecti...

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Published in:Evidence-based complementary and alternative medicine 2022-08, Vol.2022, p.1-6
Main Authors: Cao, Limei, He, Ping, Yang, Jun, Long, Xin, Chen, Yanqiu, Yan, Li, Zhou, Deping
Format: Article
Language:English
Subjects:
Age
Biopsy
Cellular biology
Cervical cancer
Colposcopy
Cytology
Disease
Hospitals
Human papillomavirus
Lesions
Medical screening
mRNA
Pathology
Patients
Remission (Medicine)
Sexual intercourse
Statistical analysis
Statistical methods
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Summary:Objective. To assess the predictive worth of HPV E6/E7 mRNA detection in the outcome of the cervical low-grade squamous intraepithelial lesion (LSIL). From September 2017 to early September 2019, patients screened for high-risk HPV positive or abnormal cervical liquid-based cytology were retrospectively analyzed and diagnosed with LSIL by cervical biopsy were recruited. The independent influencing factors of the regression of LSIL lesions after follow-up were analyzed, and the outcome of LSIL was calculated. The results of the initial colposcopy in this study were CIN I, CIN II/P16-negative, CIN II/P16-positive, and CIN III. At the time of re-examination, LSIL patients had three outcomes: regression, persistence, and progression. In the two follow-ups, 330 patients were finally included, including 276 CIN I patients (group A) and 54 CIN II/P16-negative patients (group B). The positive rates of HPV E6/E7 mRNA in each group were 66.67% and 70.37% for A and B, respectively. The total positive rate of E6/E7 mRNA was 67.27%, and there was no significant difference between the two groups (P>0.05). After 1 year follow-up, whether HPV E6/E7 mRNA regressed or was negative was associated with the outcome of LSIL-related lesions (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/8747919