A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section

Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2022-08, Vol.2022, p.1524198-5
Main Authors: Wang, Qiwei, Xiao, Maoxin, Sun, Hao, Zhang, Pengcheng
Format: Article
Language:English
Subjects:
Blood Pressure - drug effects
Cesarean Section
Depression, Postpartum - prevention & control
Female
Heart Rate - drug effects
Humans
Ketamine - administration & dosage
Ketamine - adverse effects
Ketamine - pharmacology
Postpartum Period
Pregnancy
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Summary:Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research subjects. The control group was given intravenous injection of 2 ml of normal saline after the fetus was delivered. Meanwhile, the observation group was given intravenous injection of a small dose of esketamine (esketamine 0.5 mg/kg+ 2 ml of normal saline) after the delivery of the fetus. The changes of blood pressure and heart rate, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire scores and the incidence of postpartum depression were compared between the two groups. At the same time, the incidence of postoperative adverse events in the two groups was observed. Results. There was no significant difference in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups at T1-T3 (P>0.05). Compared with the control group, the SBP, DBP, and HR at T4 and T5 in the observation group were higher (P0.05). Compared with T3, SBP, DBP, and HR were lower in control group T4 and T5, respectively. There was no significant difference in the EPDS scores between the two groups on the 1st day before delivery (P>0.05). The EPDS scores of the two groups were higher at 3d postpartum and 42d postpartum, respectively, than at 1d before delivery. The EPDS scores of the observation group at 3d and 42d after delivery were lower than those in the control group (P
ISSN:1748-670X
1748-6718
DOI:10.1155/2022/1524198