A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section

Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research...

Full description

Saved in:
Bibliographic Details
Published in:Computational and mathematical methods in medicine 2022-08, Vol.2022, p.1524198-5
Main Authors: Wang, Qiwei, Xiao, Maoxin, Sun, Hao, Zhang, Pengcheng
Format: Article
Language:English
Subjects:
Blood Pressure - drug effects
Cesarean Section
Depression, Postpartum - prevention & control
Female
Heart Rate - drug effects
Humans
Ketamine - administration & dosage
Ketamine - adverse effects
Ketamine - pharmacology
Postpartum Period
Pregnancy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3
cites cdi_FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3
container_end_page 5
container_issue
container_start_page 1524198
container_title Computational and mathematical methods in medicine
container_volume 2022
creator Wang, Qiwei
Xiao, Maoxin
Sun, Hao
Zhang, Pengcheng
description Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research subjects. The control group was given intravenous injection of 2 ml of normal saline after the fetus was delivered. Meanwhile, the observation group was given intravenous injection of a small dose of esketamine (esketamine 0.5 mg/kg+ 2 ml of normal saline) after the delivery of the fetus. The changes of blood pressure and heart rate, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire scores and the incidence of postpartum depression were compared between the two groups. At the same time, the incidence of postoperative adverse events in the two groups was observed. Results. There was no significant difference in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups at T1-T3 (P>0.05). Compared with the control group, the SBP, DBP, and HR at T4 and T5 in the observation group were higher (P0.05). Compared with T3, SBP, DBP, and HR were lower in control group T4 and T5, respectively. There was no significant difference in the EPDS scores between the two groups on the 1st day before delivery (P>0.05). The EPDS scores of the two groups were higher at 3d postpartum and 42d postpartum, respectively, than at 1d before delivery. The EPDS scores of the observation group at 3d and 42d after delivery were lower than those in the control group (P
doi_str_mv 10.1155/2022/1524198
format article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9377947</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>35979054</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3</originalsourceid><addsrcrecordid>eNp9kM1LwzAYh4Mobk5vniVHRefy2bQXYWzzAwYWpuCtZM0bV93akmST_fd2bA69eHrD-3vyhPwQOqfkllIpe4ww1qOSCZrEB6hNlYi7kaLx4f5M3lroxPsPQiRVkh6jFpeJSogUbWT6eBKWZo2rEocZ4NTBCspQrACPrIU84Mrikf-EoBdFCRssrXyotQvLBR5C7cD7otlepunwCmsbwOEBeO1Al3jSCJrwFB1ZPfdwtpsd9Ho_ehk8dsfPD0-D_ribc0lClzGiYh3lOtcsMjYiU8aZIpZoQxIKPCISTJQIKaaSxRDHseFGcW6EAMGt4R10t_XWy-kCTN58xOl5Vrtiod06q3SR_U3KYpa9V6ss4UolQjWCm60gd5X3Duz-LiXZpu1s03a2a7vBL36_t4d_6m2A6y0wK0qjv4r_dd_Ad4gd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section</title><source>Wiley Online Library Open Access</source><creator>Wang, Qiwei ; Xiao, Maoxin ; Sun, Hao ; Zhang, Pengcheng</creator><contributor>Asghar, Muhammad</contributor><creatorcontrib>Wang, Qiwei ; Xiao, Maoxin ; Sun, Hao ; Zhang, Pengcheng ; Asghar, Muhammad</creatorcontrib><description>Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research subjects. The control group was given intravenous injection of 2 ml of normal saline after the fetus was delivered. Meanwhile, the observation group was given intravenous injection of a small dose of esketamine (esketamine 0.5 mg/kg+ 2 ml of normal saline) after the delivery of the fetus. The changes of blood pressure and heart rate, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire scores and the incidence of postpartum depression were compared between the two groups. At the same time, the incidence of postoperative adverse events in the two groups was observed. Results. There was no significant difference in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups at T1-T3 (P&gt;0.05). Compared with the control group, the SBP, DBP, and HR at T4 and T5 in the observation group were higher (P&lt;0.05). There was no significant difference in SBP, DBP, and HR at T3, T4, and T5 in the observation group (P&gt;0.05). Compared with T3, SBP, DBP, and HR were lower in control group T4 and T5, respectively. There was no significant difference in the EPDS scores between the two groups on the 1st day before delivery (P&gt;0.05). The EPDS scores of the two groups were higher at 3d postpartum and 42d postpartum, respectively, than at 1d before delivery. The EPDS scores of the observation group at 3d and 42d after delivery were lower than those in the control group (P&lt;0.05). Compared with the control group, the incidence of postpartum depression was higher in the observation group at 3 days postpartum and 1 month postpartum, respectively (P&lt;0.05). There was no significant difference in the incidence of postpartum adverse reactions between the two groups (P&gt;0.05). Conclusion. The application of esketamine after cesarean section can effectively reduce depression-related scores and the risk of postpartum depression without increasing adverse reactions and has high safety.</description><identifier>ISSN: 1748-670X</identifier><identifier>EISSN: 1748-6718</identifier><identifier>DOI: 10.1155/2022/1524198</identifier><identifier>PMID: 35979054</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Blood Pressure - drug effects ; Cesarean Section ; Depression, Postpartum - prevention &amp; control ; Female ; Heart Rate - drug effects ; Humans ; Ketamine - administration &amp; dosage ; Ketamine - adverse effects ; Ketamine - pharmacology ; Postpartum Period ; Pregnancy</subject><ispartof>Computational and mathematical methods in medicine, 2022-08, Vol.2022, p.1524198-5</ispartof><rights>Copyright © 2022 Qiwei Wang et al.</rights><rights>Copyright © 2022 Qiwei Wang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3</citedby><cites>FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3</cites><orcidid>0000-0001-7670-1258 ; 0000-0001-9054-9301 ; 0000-0003-0030-3397 ; 0000-0002-5429-2091</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35979054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Asghar, Muhammad</contributor><creatorcontrib>Wang, Qiwei</creatorcontrib><creatorcontrib>Xiao, Maoxin</creatorcontrib><creatorcontrib>Sun, Hao</creatorcontrib><creatorcontrib>Zhang, Pengcheng</creatorcontrib><title>A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section</title><title>Computational and mathematical methods in medicine</title><addtitle>Comput Math Methods Med</addtitle><description>Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research subjects. The control group was given intravenous injection of 2 ml of normal saline after the fetus was delivered. Meanwhile, the observation group was given intravenous injection of a small dose of esketamine (esketamine 0.5 mg/kg+ 2 ml of normal saline) after the delivery of the fetus. The changes of blood pressure and heart rate, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire scores and the incidence of postpartum depression were compared between the two groups. At the same time, the incidence of postoperative adverse events in the two groups was observed. Results. There was no significant difference in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups at T1-T3 (P&gt;0.05). Compared with the control group, the SBP, DBP, and HR at T4 and T5 in the observation group were higher (P&lt;0.05). There was no significant difference in SBP, DBP, and HR at T3, T4, and T5 in the observation group (P&gt;0.05). Compared with T3, SBP, DBP, and HR were lower in control group T4 and T5, respectively. There was no significant difference in the EPDS scores between the two groups on the 1st day before delivery (P&gt;0.05). The EPDS scores of the two groups were higher at 3d postpartum and 42d postpartum, respectively, than at 1d before delivery. The EPDS scores of the observation group at 3d and 42d after delivery were lower than those in the control group (P&lt;0.05). Compared with the control group, the incidence of postpartum depression was higher in the observation group at 3 days postpartum and 1 month postpartum, respectively (P&lt;0.05). There was no significant difference in the incidence of postpartum adverse reactions between the two groups (P&gt;0.05). Conclusion. The application of esketamine after cesarean section can effectively reduce depression-related scores and the risk of postpartum depression without increasing adverse reactions and has high safety.</description><subject>Blood Pressure - drug effects</subject><subject>Cesarean Section</subject><subject>Depression, Postpartum - prevention &amp; control</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Ketamine - administration &amp; dosage</subject><subject>Ketamine - adverse effects</subject><subject>Ketamine - pharmacology</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><issn>1748-670X</issn><issn>1748-6718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM1LwzAYh4Mobk5vniVHRefy2bQXYWzzAwYWpuCtZM0bV93akmST_fd2bA69eHrD-3vyhPwQOqfkllIpe4ww1qOSCZrEB6hNlYi7kaLx4f5M3lroxPsPQiRVkh6jFpeJSogUbWT6eBKWZo2rEocZ4NTBCspQrACPrIU84Mrikf-EoBdFCRssrXyotQvLBR5C7cD7otlepunwCmsbwOEBeO1Al3jSCJrwFB1ZPfdwtpsd9Ho_ehk8dsfPD0-D_ribc0lClzGiYh3lOtcsMjYiU8aZIpZoQxIKPCISTJQIKaaSxRDHseFGcW6EAMGt4R10t_XWy-kCTN58xOl5Vrtiod06q3SR_U3KYpa9V6ss4UolQjWCm60gd5X3Duz-LiXZpu1s03a2a7vBL36_t4d_6m2A6y0wK0qjv4r_dd_Ad4gd</recordid><startdate>20220808</startdate><enddate>20220808</enddate><creator>Wang, Qiwei</creator><creator>Xiao, Maoxin</creator><creator>Sun, Hao</creator><creator>Zhang, Pengcheng</creator><general>Hindawi</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7670-1258</orcidid><orcidid>https://orcid.org/0000-0001-9054-9301</orcidid><orcidid>https://orcid.org/0000-0003-0030-3397</orcidid><orcidid>https://orcid.org/0000-0002-5429-2091</orcidid></search><sort><creationdate>20220808</creationdate><title>A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section</title><author>Wang, Qiwei ; Xiao, Maoxin ; Sun, Hao ; Zhang, Pengcheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood Pressure - drug effects</topic><topic>Cesarean Section</topic><topic>Depression, Postpartum - prevention &amp; control</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Ketamine - administration &amp; dosage</topic><topic>Ketamine - adverse effects</topic><topic>Ketamine - pharmacology</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qiwei</creatorcontrib><creatorcontrib>Xiao, Maoxin</creatorcontrib><creatorcontrib>Sun, Hao</creatorcontrib><creatorcontrib>Zhang, Pengcheng</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Computational and mathematical methods in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qiwei</au><au>Xiao, Maoxin</au><au>Sun, Hao</au><au>Zhang, Pengcheng</au><au>Asghar, Muhammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section</atitle><jtitle>Computational and mathematical methods in medicine</jtitle><addtitle>Comput Math Methods Med</addtitle><date>2022-08-08</date><risdate>2022</risdate><volume>2022</volume><spage>1524198</spage><epage>5</epage><pages>1524198-5</pages><issn>1748-670X</issn><eissn>1748-6718</eissn><abstract>Objective. The purpose of this study is to explore and analyze the preventive effect of esketamine on postpartum depression (PPD) after cesarean section. Methods. A total of 138 puerperae who underwent cesarean section in our hospital from February 2020 to January 2022 were selected as the research subjects. The control group was given intravenous injection of 2 ml of normal saline after the fetus was delivered. Meanwhile, the observation group was given intravenous injection of a small dose of esketamine (esketamine 0.5 mg/kg+ 2 ml of normal saline) after the delivery of the fetus. The changes of blood pressure and heart rate, the Edinburgh Postnatal Depression Scale (EPDS) questionnaire scores and the incidence of postpartum depression were compared between the two groups. At the same time, the incidence of postoperative adverse events in the two groups was observed. Results. There was no significant difference in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) between the two groups at T1-T3 (P&gt;0.05). Compared with the control group, the SBP, DBP, and HR at T4 and T5 in the observation group were higher (P&lt;0.05). There was no significant difference in SBP, DBP, and HR at T3, T4, and T5 in the observation group (P&gt;0.05). Compared with T3, SBP, DBP, and HR were lower in control group T4 and T5, respectively. There was no significant difference in the EPDS scores between the two groups on the 1st day before delivery (P&gt;0.05). The EPDS scores of the two groups were higher at 3d postpartum and 42d postpartum, respectively, than at 1d before delivery. The EPDS scores of the observation group at 3d and 42d after delivery were lower than those in the control group (P&lt;0.05). Compared with the control group, the incidence of postpartum depression was higher in the observation group at 3 days postpartum and 1 month postpartum, respectively (P&lt;0.05). There was no significant difference in the incidence of postpartum adverse reactions between the two groups (P&gt;0.05). Conclusion. The application of esketamine after cesarean section can effectively reduce depression-related scores and the risk of postpartum depression without increasing adverse reactions and has high safety.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35979054</pmid><doi>10.1155/2022/1524198</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7670-1258</orcidid><orcidid>https://orcid.org/0000-0001-9054-9301</orcidid><orcidid>https://orcid.org/0000-0003-0030-3397</orcidid><orcidid>https://orcid.org/0000-0002-5429-2091</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1748-670X
ispartof Computational and mathematical methods in medicine, 2022-08, Vol.2022, p.1524198-5
issn 1748-670X
1748-6718
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9377947
source Wiley Online Library Open Access
subjects Blood Pressure - drug effects
Cesarean Section
Depression, Postpartum - prevention & control
Female
Heart Rate - drug effects
Humans
Ketamine - administration & dosage
Ketamine - adverse effects
Ketamine - pharmacology
Postpartum Period
Pregnancy
title A Study on the Preventive Effect of Esketamine on Postpartum Depression (PPD) after Cesarean Section
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A56%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Study%20on%20the%20Preventive%20Effect%20of%20Esketamine%20on%20Postpartum%20Depression%20(PPD)%20after%20Cesarean%20Section&rft.jtitle=Computational%20and%20mathematical%20methods%20in%20medicine&rft.au=Wang,%20Qiwei&rft.date=2022-08-08&rft.volume=2022&rft.spage=1524198&rft.epage=5&rft.pages=1524198-5&rft.issn=1748-670X&rft.eissn=1748-6718&rft_id=info:doi/10.1155/2022/1524198&rft_dat=%3Cpubmed_cross%3E35979054%3C/pubmed_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c350t-22078a6caca26df60b23270f0ad091e3605ed69454b528e888d3d733d44e43fd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/35979054&rfr_iscdi=true