Access to kidney transplantation among pediatric candidates with prior solid organ transplants in the United States

• Published in: Pediatric transplantation 2022-09, Vol.26 (6), p.e14303-n/a
• Main Authors: Husain, Syed Ali, King, Kristen L., Owen‐Simon, Nina L., Fernandez, Hilda E., Ratner, Lloyd E., Mohan, Sumit
• Format: Article
• Language: English
• Subjects: Candidates; Child; Donors; Heart transplantation; Humans; kidney transplant; Kidney Transplantation; Kidney transplants; Liver transplantation; organ allocation; Organ Transplantation; pediatric transplantation; Pediatrics; Tissue and Organ Procurement; Tissue Donors; transplant wait‐list; Transplants; United States; Waiting Lists
• ISSN: 1397-3142; 1399-3046; 1399-3046
• DOI: 10.1111/petr.14303

Background Pediatric kidney transplant candidates require timely access to transplant to optimize growth and neurodevelopmental outcomes. We studied access to transplant for pediatric candidates with prior organ transplants. Methods We used US registry data to identify pediatric kidney transplant candidates added to the waiting list 2015–2019 and used competing risk regression to study the association between prior transplant status and probability of receiving a kidney transplant, treating wait‐list removal and death as competing events. Results Of 4962 pediatric kidney transplant candidates included, 89% had no prior transplant and 11% had received a prior organ transplant (kidney 87%, liver 5%, heart 5%). Prior transplant recipients were older at listing (median 15 vs. 12 years) and more likely to have PRA≥98% (22% vs. 0.3%) (both p