Atypical Location of Diffuse Large B-cell Lymphoma in the Nasal Septum

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin’s lymphoma (NHL). This subtype can be present in various extranodal sites, including the brain, bones, intestines, kidneys, adrenal glands, and other soft tissues. As demonstrated in this case, one rare site of DLBCL...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-08, Vol.14 (8)
Main Authors: Patel, Veshesh, Tacy, Collin J, Creamean, Trevor, Sibia, Adiraj, Patel, Jayesh
Format: Article
Language:English
Subjects:
Anatomy
Antibiotics
Biopsy
Case reports
Chemotherapy
Endoscopy
Fever
Immunotherapy
Lymphoma
Medical prognosis
Medicine
Monoclonal antibodies
Osteopathic medicine
Otolaryngology
Patients
Radiation therapy
Sinuses
Sinusitis
Targeted cancer therapy
Tomography
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Summary:Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin’s lymphoma (NHL). This subtype can be present in various extranodal sites, including the brain, bones, intestines, kidneys, adrenal glands, and other soft tissues. As demonstrated in this case, one rare site of DLBCL is the nasal septum, which presents as a rapidly enlarging mass resistant to antibiotics and steroids. The definitive diagnosis for this case involved biopsy, but further workup, such as computed tomography (CT) and fluorescence in situ hybridization (FISH), helped support the diagnosis of DLBCL. While determining the stage of the lymphoma, treatment with R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) was initiated immediately. This case demonstrates a rare presentation of DLBCL in the nasal septum and describes the significance of urgent examination as well as treatment.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.28085