Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies

Fatigue is one of the most debilitating symptoms for people with multiple sclerosis (PwMS). By consolidating a diverse and conflicting evidence-base, this systematic review and meta-analysis aimed to gain new insights into the neurobiology of MS fatigue. MEDLINE, ProQuest, CINAHL, Web of Science dat...

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Bibliographic Details
Published in:Neuropsychology review 2022-09, Vol.32 (3), p.506-519
Main Authors: Ellison, Paula M., Goodall, Stuart, Kennedy, Niamh, Dawes, Helen, Clark, Allan, Pomeroy, Valerie, Duddy, Martin, Baker, Mark R., Saxton, John M.
Format: Article
Language:English
Subjects:
Atrophy
Biomedical and Life Sciences
Biomedicine
Cross-sectional studies
Fatigue
Medical imaging
Meta-analysis
Multiple sclerosis
Muscles
Nervous system
Neuroimaging
Neurology
Neurophysiology
Neuropsychology
Neurosciences
Online databases
Putamen
Review
Skeletal muscle
Substantia grisea
Systematic review
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Summary:Fatigue is one of the most debilitating symptoms for people with multiple sclerosis (PwMS). By consolidating a diverse and conflicting evidence-base, this systematic review and meta-analysis aimed to gain new insights into the neurobiology of MS fatigue. MEDLINE, ProQuest, CINAHL, Web of Science databases and grey literature were searched using Medical Subject Headings. Eligible studies compared neuroimaging and neurophysiological data between people experiencing high (MS-HF) versus low (MS-LF) levels of perceived MS fatigue, as defined by validated fatigue questionnaire cut-points. Data were available from 66 studies, with 46 used for meta-analyses. Neuroimaging studies revealed lower volumetric measures in MS-HF versus MS-LF for whole brain (­22.74 ml; 95% CI: -37.72 to -7.76 ml; p  = 0.003), grey matter (­18.81 ml; 95% CI: ­29.60 to ­8.03 ml; p  
ISSN:1040-7308
1573-6660
DOI:10.1007/s11065-021-09508-1