Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut mi...

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Bibliographic Details
Published in:The ISME Journal 2022-09, Vol.16 (9), p.2181-2197
Main Authors: Mayneris-Perxachs, Jordi, Arnoriaga-Rodríguez, María, Garre-Olmo, Josep, Puig, Josep, Ramos, Rafael, Trelis, Maria, Burokas, Aurelijus, Coll, Clàudia, Zapata-Tona, Cristina, Pedraza, Salvador, Pérez-Brocal, Vicente, Ramió, Lluís, Ricart, Wifredo, Moya, Andrés, Jové, Mariona, Sol, Joaquim, Portero-Otin, Manuel, Pamplona, Reinald, Maldonado, Rafael, Fernández-Real, José Manuel
Format: Article
Language:English
Subjects:
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Aging
Amino acids
Bacteria
Biomedical and Life Sciences
Biomedical research
Blastocystis
Body mass index
Bowel disease
Brain research
Cognition
Cognitive ability
Committees
Consent
Cortex gene
Diabetes
Ecology
Endocrinology
Ethics
Evolutionary Biology
Executive function
Folic acid
Gene expression
Hospitals
Intestinal microflora
Life Sciences
Medical research
Metabolism
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiomes
Microbiota
Parasites
Pharmacy
Prefrontal cortex
Public health
Research centers
Review boards
Transplantation
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Summary:Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery ( n  = 114) and replication cohorts ( n  = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis -associated shifts in bacterial functionality translated into the circulating metabolome. Finally, we evaluated the effects of microbiota transplantation. Donor’s Blastocystis subtypes led to altered recipient’s mice cognitive function and prefrontal cortex gene expression. In summary, Blastocystis warrant further consideration as a novel actor in the gut microbiome-brain axis.
ISSN:1751-7362
1751-7370
DOI:10.1038/s41396-022-01262-3