Synthesis of a Zirconium Complex of an N,O‑type p-tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

The synthesis and characterization of a new octahedral Zr­(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffract...

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Published in:ACS omega 2022-08, Vol.7 (32), p.28471-28480
Main Authors: Rawat, Varun, Vigalok, Arkadi, Sinha, Anshu Kumar, Sachdeva, Garima, Srivastava, Chandra Mohan, Rao, Gyandshwar K., Kumar, Arun, Singh, Mandeep, Rathi, Komal, Verma, Ved Prakash, Yadav, Bhupender, Pandey, Amit Kumar, Vats, Monika
Format: Article
Language:English
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Summary:The synthesis and characterization of a new octahedral Zr­(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis­(indolyl)­methanes, and coumarins. This complex (Cl2Zr–calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti­(IV) and Zn­(II) analogues. Ferrocene-appended bis­(indolyl)­methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.2c03187