The Essential Role of FoxO1 in the Regulation of Macrophage Function

Macrophages are widely distributed in various tissues and organs. They not only participate in the regulation of innate and adaptive immune response, but also play an important role in tissue homeostasis. Dysregulation of macrophage function is closely related to the initiation, development and prog...

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Bibliographic Details
Published in:BioMed research international 2022, Vol.2022 (1), p.1068962-1068962
Main Authors: Rong, Shan Jie, Yang, Chun Liang, Wang, Fa Xi, Sun, Fei, Luo, Jia Hui, Yue, Tian Tian, Yang, Ping, Yu, Qilin, Zhang, Shu, Wang, Cong-Yi
Format: Article
Language:English
Subjects:
Ablation
Adaptive immunity
Apoptosis
Autophagy
Biological activity
Biomedical research
Bone marrow
Cell cycle
Cell proliferation
Cytokines
Enzymes
Forkhead protein
FOXO1 protein
Homeostasis
Immune response
Inflammation
Leukocyte migration
Lymphocytes
Macrophages
Metabolism
Pathogens
Phagocytosis
Phosphorylation
Physiological aspects
Post-translation
Proteins
Review
Transcription factors
Tumorigenesis
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Summary:Macrophages are widely distributed in various tissues and organs. They not only participate in the regulation of innate and adaptive immune response, but also play an important role in tissue homeostasis. Dysregulation of macrophage function is closely related to the initiation, development and prognosis of multiple diseases, including infection and tumorigenesis. Forkhead box transcription factor O1 (FoxO1) is an important member among the forkhead box transcription factor family. Through directly binding to the promoter regions of downstream target genes, FoxO1 is implicated in cell proliferation, apoptosis, metabolic activities and other biological processes. In this review, we summarized the regulatory role of FoxO1 in macrophage phagocytosis, migration, differentiation and inflammatory activation. We also emphasized that macrophage reciprocally modulated FoxO1 activity via a post-translational modification (PTM) dominant manner.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/1068962