Prevalence of neuropsychiatric symptoms and stroke in patients with hereditary thrombotic thrombocytopenic purpura

In this article, Borogovac et al emphasized the burden of stroke and neuropsychiatric symptoms in patients with hereditary thrombotic thrombocytopenic purpura (hTTP) based on an analysis of the International hTTP Registry. Given the rarity of hTTP, patient numbers were small; nevertheless, the preva...

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Bibliographic Details
Published in:Blood 2022-08, Vol.140 (7), p.785-789
Main Authors: Borogovac, Azra, Tarasco, Erika, Kremer Hovinga, Johanna A., Friedman, Kenneth D., Asch, Adam S., Vesely, Sara K., Prodan, Calin I., Terrell, Deirdra R., George, James N.
Format: Article
Language:English
Subjects:
ADAMTS13 Protein
Humans
Letter to Blood
Prevalence
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - epidemiology
Purpura, Thrombotic Thrombocytopenic - genetics
Stroke - epidemiology
Stroke - genetics
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Summary:In this article, Borogovac et al emphasized the burden of stroke and neuropsychiatric symptoms in patients with hereditary thrombotic thrombocytopenic purpura (hTTP) based on an analysis of the International hTTP Registry. Given the rarity of hTTP, patient numbers were small; nevertheless, the prevalence of stroke reached 100% in patients over the age of 50. Nearly all patients also had evidence of neuropsychiatric symptoms. These data confirm the need to diagnose hTTP as early as possible and support the use of prophylaxis to prevent future events.
ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2022016044