Is it safe and effective to administer COVID-19 vaccines during pregnancy? A systematic review and meta-analysis

•COVID-19 vaccination prevents infection and hospitalizations in pregnant patients.•COVID- 19 vaccine is protective against neonatal COVID-19 I.C.U. admissions.•Canada showed significant decrease in neonatal ICU admissions after vaccination of mothers.•There is a significant decrease in preterm birt...

Full description

Saved in:
Bibliographic Details
Published in:American journal of infection control 2023-05, Vol.51 (5), p.582-593
Main Authors: Hameed, Ishaque, Khan, Mohammad Omer, Nusrat, Khushboo, Mahmood, Samar, Nashit, Muhammad, Malik, Shanza, Siddiqui, Omer Mustafa, Samad, Syed Abdus, Marsia, Shayan, Usman, Muhammad Shariq, Siddiqi, Tariq Jamal
Format: Article
Language:English
Subjects:
Adverse outcomes
Cesarean Section
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Delivery, Obstetric
Efficacy
Female
Humans
Infant, Newborn
Pregnancy
Safety
SARS-CoV-2
State of the Science Review
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•COVID-19 vaccination prevents infection and hospitalizations in pregnant patients.•COVID- 19 vaccine is protective against neonatal COVID-19 I.C.U. admissions.•Canada showed significant decrease in neonatal ICU admissions after vaccination of mothers.•There is a significant decrease in preterm births when patients were vaccinated in the third trimester.•There was a significant decrease noted in COVID-19 infection after receiving the vaccination in all locations except England. To evaluate the safety and efficacy of COVID-19 vaccines in pregnant women performing an updated meta-analysis. We searched PubMed, Cochrane Central, and SCOPUS from inception to March 2022. Outcomes of interest were incidence of adverse maternal, fetal and neonatal consequences pertaining to safety of the vaccines. Secondarily, we analyzed the number of SARS-CoV-2 infections, hospitalization for COVID-19, and admission to the I.C.U. for COVID-19 assessing the effectiveness of vaccines. Results were pooled using a random effects model. Ten observational studies (n=326,499) analyzing pregnant women were included. Our results suggest that COVID-19 vaccination prevents infection (OR: 0.56, 95% CI: 0.47, 0.67; P = 
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2022.08.014