Relationships Between Muscle Parameters and History of Falls and Fractures in the Hertfordshire Cohort Study: Do All Muscle Components Relate Equally to Clinical Outcomes?

• Published in: Calcified tissue international 2022-09, Vol.111 (3), p.242-247
• Main Authors: Laskou, Faidra, Westbury, Leo D., Fuggle, Nicholas R., Edwards, Mark H., Cooper, Cyrus, Dennison, Elaine M.
• Format: Article
• Language: English
• Subjects: Age; Aged; Biochemistry; Biomedical and Life Sciences; Cell Biology; Clinical outcomes; Cohort analysis; Cohort Studies; Computed tomography; Endocrinology; Falls; Female; Females; Fractures; Fractures, Bone; Gait; Hand Strength - physiology; Humans; Life Sciences; Male; Middle Aged; Muscle Strength - physiology; Muscle, Skeletal - physiology; Original Research; Orthopedics; Sarcopenia; Sexual dimorphism; Statistical analysis
• ISSN: 1432-0827; 0171-967X; 1432-0827
• DOI: 10.1007/s00223-022-00986-w

In previous work, relationships between muscle and bone size and strength have been demonstrated and were stronger in females, suggesting possible sexual dimorphism. Here we examine sex-specific associations between individual muscle sarcopenia components with clinical outcomes (falls and fractures). 641 participants were recruited. Muscle mass was assessed as cross-sectional area (CSA) by peripheral quantitative computed tomography of the calf, grip strength (GpS) by Jamar dynamometry and function by gait speed (GtS). Falls and fractures were self-reported. Ordinal and logistic regression were used to examine the associations between muscle measurements and outcomes with and without adjustment for confounders. Mean (SD) age was 69.3 (2.6) years. CSA, GpS, and GtS were greater among males ( p