Treatment of bone defects with bovine hydroxyapatite xenograft and platelet rich fibrin (PRF) to accelerate bone healing

• Published in: International journal of surgery case reports 2022-08, Vol.97, p.107370-107370, Article 107370
• Main Authors: Taufik S, Ahmad, Wiweko, Adnanto, Yudhanto, Didit, Rizki, Mohammad, Habib, Philip, Dirja, Bayu Tirta, Rosyidi, Rohadi Muhammad
• Format: Article
• Language: English
• Subjects: Bone defects; Bovine hydroxyapatite xenograft; Case Report; Platelet-rich fibrin
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2022.107370

The autograft treatment has become a gold standard therapy for bone defects, although it has its drawbacks and a side effect of donor site morbidity. Furthermore, the bovine hydroxyapatite xenograft due to its excellent osteoconduction characteristic combined with platelet-rich fibrin (PRF), which is a source of growth factor, makes both utilized as therapeutic measures. Therefore, this study examines the potential use of bovine hydroxyapatite xenograft and platelet-rich fibrin in the treatment of bone defects. The report on three cases of bone defects that were treated using a combination of bovine hydroxyapatite xenograft and platelet-rich fibrin (PRF) for internal fixation and grafting was used for this investigation. The study showed that delayed and non-union fractures of the femur, humerus, and tibia may cause bone deformities. The outcome revealed a positive clinical and radiological finding about using the combination of bovine hydroxyapatite xenograft and platelet-rich fibrin (PRF) in the repair of bone defects and acceleration of healing processes. The use of a combination of bovine hydroxyapatite xenograft and platelet-rich fibrin (PRF) in the repair of bone defects shows more effective and accelerated healing. Future studies with a bigger sample size may be carried out and are expected to yield optimal results. •Bone defects are still a major issue•There is a potential use of bovine hydroxyapatite xenograft and platelet-rich fibrin in the treatment of bone defects•The combination of bovine hydroxy apatite xenograft and PRF fulfill the requirements for the promotion of bone regeneration•The combination of bovine hydroxyapatite xenograft and platelet-rich fibrin (PRF) on the treatment of bone defects led to the achievement of outstanding results with good radiological and clinical backings