A Novel Method for Detecting Duchenne Muscular Dystrophy in Blood Serum of mdx Mice

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, typically affecting males in infancy. The disease causes progressive weakness and atrophy of skeletal muscles, with approximately 20,000 new cases diagnosed yearly. Currently, methods for diagnosing DMD are invasive, la...

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Bibliographic Details
Published in:Genes 2022-07, Vol.13 (8), p.1342
Main Authors: Ralbovsky, Nicole M., Dey, Paromita, Galfano, Andrew, Dey, Bijan K., Lednev, Igor K.
Format: Article
Language:English
Subjects:
Alcohol
Alzheimer's disease
Anticoagulants
Atrophy
Discriminant analysis
Duchenne's muscular dystrophy
Enzymes
Laboratories
Muscular dystrophy
Protocol
Raman spectroscopy
Rodents
Skeletal muscle
Spectrum analysis
Veins & arteries
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Summary:Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, typically affecting males in infancy. The disease causes progressive weakness and atrophy of skeletal muscles, with approximately 20,000 new cases diagnosed yearly. Currently, methods for diagnosing DMD are invasive, laborious, and unable to make accurate early detections. While there is no cure for DMD, there are limited treatments available for managing symptoms. As such, there is a crucial unmet need to develop a simple and non-invasive method for accurately detecting DMD as early as possible. Raman spectroscopy with chemometric analysis is shown to have the potential to fill this diagnostic need.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13081342