Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails

A ketogenic diet, characterized by low calories with high levels of fat, adequate levels of protein, and low levels of carbohydrates, has beneficial effects on body weight control in overweight patients. In the present study, a meta-analysis was conducted to investigate the role of a ketogenic diet...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-08, Vol.19 (16), p.10429
Main Authors: Zhou, Chong, Wang, Meng, Liang, Jiling, He, Guomin, Chen, Ning
Format: Article
Language:English
Subjects:
Bias
Body mass index
Body weight
Body weight loss
Calories
Carbohydrates
Clinical trials
Confidence intervals
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetic neuropathy
Diet
Glucose
Hemoglobin
High density lipoprotein
High fat diet
Hypocaloric diet
Insulin resistance
Intervention
Ketogenesis
Lipids
Lipoproteins
Low carbohydrate diet
Meta-analysis
Metabolism
Nutrient deficiency
Nutrition research
Obesity
Oils & fats
Overweight
Proteins
Review
Triglycerides
Weight control
Weight loss
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Summary:A ketogenic diet, characterized by low calories with high levels of fat, adequate levels of protein, and low levels of carbohydrates, has beneficial effects on body weight control in overweight patients. In the present study, a meta-analysis was conducted to investigate the role of a ketogenic diet in body weight control and glycemic management in overweight patients with type 2 diabetes mellitus (T2DM). In summary, we systematically reviewed articles from the Embase, PubMed, Web of Science and Cochrane Library databases and obtained eight randomized controlled trials for meta-analysis. The results show that a ketogenic diet had significantly beneficial effects on the loss of body weight (SMD, −5.63, p = 0.008), the reduction of waist circumference (SMD, −2.32, p = 0.04), lowering glycated hemoglobin (SMD, −0.38, p = 0.0008) and triglycerides (SMD, −0.36, p = 0.0001), and increasing high-density lipoproteins (SMD, 0.28, p = 0.003). Overall, these results suggest that a ketogenic diet may be an effective dietary intervention for body weight and glycemic control, as well as improved lipid profiles in overweight patients with T2DM. Hence, a ketogenic diet can be recommended for the therapeutic intervention of overweight patients with T2DM.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph191610429