Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats

Over the past century, the average age for onset of puberty has declined. Several additives present in our food are thought to contribute significantly to this early puberty which is recognized to also affect people’s health in later life. On this basis, the impact of 40-days unique oral administrat...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-08, Vol.19 (16), p.10410
Main Authors: Mindang, Elisabeth Louise Ndjengue, Awounfack, Charline Florence, Ndinteh, Derek Tantoh, Krause, Rui W. M., Njamen, Dieudonne
Format: Article
Language:English
Subjects:
Additives
Age
Animals
Cancer
Children & youth
Cholesterol
Consumption
Cosmetics
Diet
Drug dosages
Endocrine disruptors
Estrogens
Females
Fertility
Follicles
Folliculogenesis
Food additives
Food dyes
Food industry
Food processing
Hormones
Hypothalamus
Maturation
Nutrition research
Oral administration
Ovaries
Ovulation
Pituitary
Pituitary (anterior)
Processed foods
Puberty
Reproductive organs
Rodents
Sex hormones
Sperm
Tartrazine
Uterus
Vagina
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Summary:Over the past century, the average age for onset of puberty has declined. Several additives present in our food are thought to contribute significantly to this early puberty which is recognized to also affect people’s health in later life. On this basis, the impact of 40-days unique oral administration of the food dye tartrazine (7.5, 27, and 47 mg/kg BW doses) was evaluated on some sexual maturation parameters on immature female Wistar rats. Vaginal opening was evaluated during the treatment period. At the end of the treatments, animals were sacrificed (estrus phase) and the relative weight of reproductive organs, pituitary gonadotrophin and sexual steroids level, cholesterol level in ovaries and folliculogenesis were evaluated. Compared to the control group, animals receiving tartrazine (47 mg/kg BW) showed significantly high percentage of early vaginal opening from day 45 of age, and an increase in the number of totals, primaries, secondaries, and antral follicles; a significant increase in serum estrogen, LH and in uterine epithelial thickness. Our findings suggest that tartrazine considerably disturbs the normal courses of puberty. These results could validate at least in part the global observations on increasingly precocious puberty in girls feeding increasingly with industrially processed foods.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph191610410