Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox de...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-08, Vol.23 (16), p.9093
Main Authors: Demin, Alexander M., Vakhrushev, Alexander V., Pershina, Alexandra G., Valova, Marina S., Efimova, Lina V., Syomchina, Alexandra A., Uimin, Mikhail A., Minin, Artem S., Levit, Galina L., Krasnov, Victor P., Charushin, Valery N.
Format: Article
Language:English
Subjects:
Cancer
Cytotoxicity
Doxorubicin
Efficiency
Hyperthermia
Iron oxides
Nanocomposites
Nanomaterials
Nanoparticles
Nanotechnology
Polyethylene glycol
Polyvinyl alcohol
Scientific imaging
Silicon dioxide
Succinic acid
Tumor cell lines
Tumor cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23169093