Office-Based Structural Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Unilateral vocal fold paralysis (UVFP) is a common cause of incomplete glottic closure, leading to significant somatic and social disabilities. Office-based autologous fat injection laryngoplasty (AFIL) has been proposed as an effective treatment for glottic insufficiency but has not been well-studi...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-08, Vol.11 (16), p.4806
Main Authors: Chen, Andy Wei-Ge, Chen, Chih-Hua, Lin, Tsai-Ming, Chang, Angela Chih-Hui, Tsai, Tzu-Pei, Chang, Shyue-Yih
Format: Article
Language:English
Subjects:
Cancer
Cartilage
Catheters
Clinical medicine
COVID-19
Disability
Endoscopy
Epidural
General anesthesia
Larynx
Liposuction
Local anesthesia
Medical prognosis
Patients
Software
Speech therapists
Surgery
Surgical outcomes
Thyroid gland
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Summary:Unilateral vocal fold paralysis (UVFP) is a common cause of incomplete glottic closure, leading to significant somatic and social disabilities. Office-based autologous fat injection laryngoplasty (AFIL) has been proposed as an effective treatment for glottic insufficiency but has not been well-studied for UVFP. We enrolled 23 patients who underwent office-based structural AFIL due to unilateral vocal paralysis at our institution between February 2021 and January 2022. In the procedure, autologous fat was harvested and injected into the vocal fold under the guidance of flexible digital endoscopy for structural fat grafting. The voice handicap index-10 (VHI-10) score and perceptual voice measurements were collected before the operation, 2 weeks postoperatively, and 3 months postoperatively. Twenty-two patients were followed-up for at least 3 months. The VHI-10 score improved significantly from 29.65 ± 8.52 preoperatively to 11.74 ± 7.42 at 2 weeks (p < 0.0001) and 5.36 ± 6.67 at 3 months (p < 0.0001). Significant improvements in grades of dysphonia (p < 0.0001), breathiness (p < 0.0001), and asthenia (p = 0.004) were also noted at 3 months postoperatively when perceptual measurements were investigated. Office-based structural AFIL is an effective treatment for improving voice-related disability for UVFP patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11164806