Role of Lipid-Lowering Therapy in Peripheral Artery Disease

Atherosclerosis is a multifactorial, lipoprotein-driven condition that leads to plaque formation within the arterial tree, leading to subsequent arterial stenosis and thrombosis that accounts for a large burden of cardiovascular morbidity and mortality globally. Atherosclerosis of the lower extremit...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-08, Vol.11 (16), p.4872
Main Authors: Belur, Agastya D., Shah, Aangi J., Virani, Salim S., Vorla, Mounica, Kalra, Dinesh K.
Format: Article
Language:English
Subjects:
Amputation
Atherosclerosis
Clinical medicine
Lipids
Mortality
Review
Statins
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Summary:Atherosclerosis is a multifactorial, lipoprotein-driven condition that leads to plaque formation within the arterial tree, leading to subsequent arterial stenosis and thrombosis that accounts for a large burden of cardiovascular morbidity and mortality globally. Atherosclerosis of the lower extremities is called peripheral artery disease and is a major cause of loss in mobility, amputation, and critical limb ischemia. Peripheral artery disease is a common condition with a gamut of clinical manifestations that affects an estimated 10 million people in the United States of America and 200 million people worldwide. The role of apolipoprotein B-containing lipoproteins, such as LDL and remnant lipoproteins in the development and progression of atherosclerosis, is well-established. The focus of this paper is to review existing data on lipid-lowering therapies in lower extremity atherosclerotic peripheral artery disease.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11164872