Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression

The special microenvironment of a solid tumor promotes the orientation and colonization of facultative anaerobes. Intratumoral bacterial infection disrupts the local vascular system to form a thrombus, resulting in darkened tumor sites and enhanced near-infrared absorption. Based on this, we constru...

Full description

Saved in:
Bibliographic Details
Published in:Nanoscale advances 2022-03, Vol.4 (6), p.1577-1586
Main Authors: Xu, Wenxuan, Ren, Debao, Yu, Zimeng, Hou, Jia, Huang, Fan, Gan, Tingfang, Ji, Ping, Zhang, Cheng, Ma, Lixin, Hu, Yunhong
Format: Article
Language:English
Subjects:
Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The special microenvironment of a solid tumor promotes the orientation and colonization of facultative anaerobes. Intratumoral bacterial infection disrupts the local vascular system to form a thrombus, resulting in darkened tumor sites and enhanced near-infrared absorption. Based on this, we constructed thermally-induced bacteria (TIB) to express programmed cell death protein 1 (PD1) at tumor tissue sites. Under laser irradiation, the elevated temperature at the tumor site not only caused damage to tumor cells but also induced the expression of PD1. Expressed PD1 bound to the ligand of PD1 (PD-L1) on the tumor cell surface and facilitated its internalization and reduction, thereby relieving immune suppression in the tumor microenvironment. Through the combined effects of photothermal therapy and immune activation, the ingenious TIB@PD1 approach greatly inhibited the proliferation and metastasis of tumor cells. Therefore, bacteria-based photothermal immunotherapy represents an appealing method for tumor therapy with good specificity and selectivity.
ISSN:2516-0230
2516-0230
DOI:10.1039/D1NA00857A