Vancomycin as an Antibacterial Agent Capped with Silver Nanoparticles: An Experimental Potential Analysis

• Published in: BioMed research international 2022, Vol.2022 (1), p.3682757
• Main Authors: Patwekar, Mohsina, Patwekar, Faheem, Alghamdi, Saad, Kamal, Mehnaz, Allahyani, Mamdouh, Almehmadi, Mazen, Kabrah, Ahmed, Dablool, Anas S., Alsaiari, Ahad Amer, Jawaid, Talha, Medikeri, Anuradha, Samuel, Krupa, Islam, Fahadul
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibacterial agents; Antibacterial materials; Antibiotic resistance; Antibiotics; Antimicrobial agents; Bacteria; Bacterial diseases; Bacterial infections; Biomedical research; Chemical reduction; Coliforms; Diffusion; Dosage and administration; E coli; Escherichia coli; Glycopeptides; Gram-negative bacteria; Gram-positive bacteria; Health aspects; Humans; Infections; Ionic surface active agents; Metal Nanoparticles - chemistry; Methicillin; Microbial Sensitivity Tests; Multidrug resistance; Nanoparticles; Nitrates; Public health; Reagents; Silver; Silver - pharmacology; Silver nitrate; Sodium citrate; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus infections; Vancomycin; Vancomycin - chemistry; Vancomycin - pharmacology
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2022/3682757

For the treatment of various infections, a variety of antimicrobial drugs are formulated. Nevertheless, many bacterial infections now exhibit antibiotic resistance due to the widespread utilization antibiotics. Methicillin-resistant among the most dangerous multidrug-resistant bacteria is Staphylococcus aureus (MRSA). Vancomycin became a viable therapy option due to MRSA resistance to methicillin medicines. One of the well-informed antibacterial compounds with wideband antibacterial activity is silver nanoparticles (AgNPs). AgNPs are thus suitable candidates for usage in conjunction alongside vancomycin to increase its antibacterial effect. The goal of the present research work is to boost the antibacterial potency of the glycopeptide antibiotic vancomycin towards Gram-positive (Staphylococcus aureus) but also Gram-negative (Escherichia coli) bacteria. The chemical reduction approach is used to create a colloidal solution of silver nanoparticles utilizing silver nitrate as a precursor in the environment of the ionic surfactant trisodium citrate that serves as covering including reducing reagent. Vancomycin was used to functionalize the synthesized nanoparticles and create the nanodrug complex (Van@AgNPs). The synergistic antibacterial potential of silver nanoparticles coated with vancomycin on both test pathogens was investigated using the agar well diffusion technique. The antibacterial potency for both classes of bacteria has significantly increased, according to the well diffusion test. It has been noted that this improvement is synergistic instead of additive.