Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam

• Published in: Annals of medicine and surgery 2022-08, Vol.80, p.104224-104224, Article 104224
• Main Authors: Nguyen Van, Dang, Le Van, Quang, Nguyen Thi Thu, Nhung, Bui Van, Giang, Ta Van, To
• Format: Article
• Language: English
• Subjects: Cross-sectional Study; Definitive concurrent chemoradiotherapy; Multiple primary cancers; Oral cavity cancer; Squamous cell carcinoma; Synchronous cancer
• ISSN: 2049-0801; 2049-0801
• DOI: 10.1016/j.amsu.2022.104224

Multiple primary squamous cell carcinomas (MPSCs) of the oral cavity are very uncommon in clinical practice. This study describes the clinical features, imaging, and treatment characteristics of the oral cavity with MPSCs at the same time of diagnosis in our center. Besides, we review the literature and prior studies on MPSCs. A retrospective, descriptive study from January 2019 to December 2021 was conducted on seven patients with MPSCs of the oral cavity at the time of their first diagnosis. Evaluation of the patient's characteristics, the treatment plan, the response to treatment, and the overall survival (OS). Seven male patients ranging in age from 43 to 70 years (Mean: 53.5). Positron Emission Tomography/Computed Tomography (PET/CT) revealed a significantly increased standardized uptake value (SUV) in the index tumor (SUVi = 15.76 ± 1.96). The index tumor is often staged T3, T4; whereas the synchronous tumor is typically staged T1, T2. All patients had concurrent chemoradiotherapy (CCRT) and achieved a partial response in all cases. Mean OS was 14.71 ± 11.85 months. MPSCs of the oral cavity at the time of diagnosis are uncommon and associated with a poor prognosis for patients. Comprehensive clinical examination, combined imaging diagnostics, with PET/CT being critical for detecting the second lesion, particularly in patients with an advanced index tumor. •Multiple primary squamous cell carcinomas of the oral cavity are a rare disease.•PETCT showed higher SUV in index tumor. The stage of the index tumor is T3, T4; the synchronous tumor stage is T1, T2.•All patients were treated by definitive CCRT; all got a partial response. Mean OS was 14.71 ± 1.85 months.