Association between Three Therapeutic Strategies and Clinical Outcomes of 2009 FIGO Stage IB2/IIA2 Cervical Cancer

Objective. The aim of this study was to compare clinical outcomes of three therapeutic strategies in patients with stage IB2/IIA2 cervical cancer. Methods. This is a retrospective cohort study. Patients diagnosed with stage IB2/IIA2 cervical cancer between April 2010 and December 2015 at First Affil...

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Bibliographic Details
Published in:Journal of oncology 2022-08, Vol.2022, p.1-8
Main Authors: Zhang, Yong, Tang, Xiaobi, Ma, Shanshan, Shen, Meizhu, Jiang, Li, Yuan, Wenchao, Wang, Rensheng, Wu, Fang
Format: Article
Language:English
Subjects:
Adjuvant treatment
Age
Blood clots
Cancer
Cancer patients
Cancer therapies
Care and treatment
Cervical cancer
Chemotherapy
Clinical outcomes
Costs
Development and progression
Drug dosages
Hemoglobin
Histology
Hospitalization
Hospitals
Hysterectomy
Length of stay
Lymphatic system
Magnetic resonance imaging
Medical colleges
Medical prognosis
Medical research
Medicine, Experimental
Metastasis
Patient outcomes
Patients
Radiation therapy
Surgery
Tomography
Tumors
Vagina
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Summary:Objective. The aim of this study was to compare clinical outcomes of three therapeutic strategies in patients with stage IB2/IIA2 cervical cancer. Methods. This is a retrospective cohort study. Patients diagnosed with stage IB2/IIA2 cervical cancer between April 2010 and December 2015 at First Affiliated Hospital of Guangxi Medical University were included and classed into three groups. The primary outcomes were overall survival (OS) and progression-free survival (PFS). The secondary outcomes included toxicity, hospitalization costs, clinical value, and length of stay. Results. 206 patients were included: 104 used primary surgical treatment (PST), 53 used neoadjuvant chemotherapy followed by radical surgery (NAC + RS), and 49 used concurrent chemoradiotherapy (CCRT). Fewer patients with NAC + RS had deep cervical stromal invasion than primary surgical treatment (PST) (P=0.024). 70.2% of PST and 77.4% in NAC + RS required postoperative radiotherapy or chemoradiotherapy (P=0.634). Median follow-up was 57 months and the 3-year OS and PFS in PST, NAC + RS, and CCRT group were 87.5%, 84.9%, 85.7% and 85.6%, 79.2%, 85.7% (P=0.856 and P=0.424, respectively). Three therapeutic strategies were not associated with OS and PFS. Hospitalization costs were significantly higher in NAC + RS compared to PST (P
ISSN:1687-8450
1687-8450
DOI:10.1155/2022/9497798