The Effect of Age on IVF-ET Outcome in Infertile Patients with PCOS Based on Tiangui Theory in Chinese Medicine

Objective. Our aim was to investigate the effect of age on the outcome of IVF-ET and ICSI in infertile PCOS patients under the guidance of Tiangui theory in traditional Chinese medicine. Method. This was a retrospective analysis of 532 infertile women with PCOS and 1,392 women with infertility due t...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022-08, Vol.2022, p.1-7
Main Authors: Chang, Hui, Li, Jian, Wu, Qi, Fu, Xin, Zhu, Mengyi, Ge, Hang, Shi, Baichao, Shao, Xiaoguang, Han, Yanhua
Format: Article
Language:English
Subjects:
17β-Estradiol
Abortion
Age
Birth rate
Chinese medicine
Chorionic gonadotropin
Developmental stages
Drug dosages
Embryos
Females
Fertility
Fertilization
Follicles
Gonadotropins
In vitro fertilization
Infertility
Menstruation
Oocytes
Ovaries
Ovulation
Patients
Pituitary (anterior)
Polycystic ovary syndrome
Pregnancy
Reproductive technologies
Sperm
Traditional Chinese medicine
Ultrasonic imaging
Womens health
Zygotes
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Summary:Objective. Our aim was to investigate the effect of age on the outcome of IVF-ET and ICSI in infertile PCOS patients under the guidance of Tiangui theory in traditional Chinese medicine. Method. This was a retrospective analysis of 532 infertile women with PCOS and 1,392 women with infertility due to tubal factors as the controls. All of the participants were divided into different age groups-aged 20–28 years, 29–35 years, and ≥36 years-according to the stages of female reproductive development in Tiangui theory as described in the Canon of Internal Medicine-Treatise of Ancient Natural Truth. We explored the effect of age on controlled ovarian hyperstimulation (including the initial dosage and duration of Gn and the estradiol level on the day of human chorionic gonadotropin administration); the numbers of retrieved oocytes, 2PN zygotes, and embryos; and the rates of fertilization, clinical pregnancy, abortion, live birth, and OHSS incidence. Results. Compared to controls, the maximum follicular diameter and the numbers of follicles with d ≥ 20 mm, retrieved oocytes, and 2PN zygotes were greater in the PCOS group with age >28 years (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/2977636