Clinical Significance of EZH2 in Acute Myeloid Leukemia

In this paper, we have focused on the investigation of the expression level of the enhancer of zeste homolog 2 (EZH2) gene in bone marrow mononuclear cells of acute myeloid leukemia (AML) patients and analyze the relationship between EZH2 gene expression and EMI. The expression of EZH2mRNA in bone m...

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Bibliographic Details
Published in:Computational intelligence and neuroscience 2022-08, Vol.2022, p.1-5
Main Authors: Jiao, Weiyun, Liu, Yuanyuan, Bao, Yangyi
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Bone marrow
Cell migration
Chemotherapy
Clinical significance
Diseases
EZH2 gene
Gene expression
Genes
Homology
Karyotypes
Leukemia
Leukocytes (mononuclear)
Medical prognosis
Patients
Protein expression
Relapse
Risk groups
RNA
Statistical analysis
Statistics
Survival analysis
Tumors
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Summary:In this paper, we have focused on the investigation of the expression level of the enhancer of zeste homolog 2 (EZH2) gene in bone marrow mononuclear cells of acute myeloid leukemia (AML) patients and analyze the relationship between EZH2 gene expression and EMI. The expression of EZH2mRNA in bone marrow mononuclear cells of 26 patients with incipient AML was detected by qRT-PCR, and the relationship between EZH2mRNA expression and clinical characteristics was analyzed. EZH2 mRNA expression was increased in 26 AML patients. EZH2 gene expression in male patients was significantly higher than that in female patients. The expression of EZH2 in the group with extramedullary infiltration (EMI) was significantly higher than that in the group without EMI. The patients were divided into different groups according to the chromosomal karyotype and prognosis. Statistical analysis showed that the expression level of the medium-risk group was significantly higher than that of the low-risk group, while there was no statistical difference in other groups (P>0.05). The expression of EZH2 gene in AML patients was closely related to EMI, and the expression of EZH2 in AML cells was closely related to cell migration ability. EZH2 is expected to be one of the indicators of disease recurrence.
ISSN:1687-5265
1687-5273
DOI:10.1155/2022/8741989