The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management

Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2023-10, Vol.15 (5), p.1298-1311
Main Authors: Mohd Fuad, Aalina Sakiinah, Amran, Nurul Aqilah, Nasruddin, Nurrul Shaqinah, Burhanudin, Nor Aszlitah, Dashper, Stuart, Arzmi, Mohd Hafiz
Format: Article
Language:English
Subjects:
alcohol abuse
Antibacterial activity
antibacterial properties
antibiotic resistance
Antimicrobial resistance
Applied Microbiology
biofilm
Biofilms
Biomedical and Life Sciences
Candidiasis
Carcinogenesis
Chemistry/Food Science
disease prevention
Dysbacteriosis
dysbiosis
Hygiene
inflammation
Life Sciences
Microbiology
microbiome
Microbiomes
mouth neoplasms
Nutrition
Oral cancer
Oral hygiene
Oral infection
Periodontitis
Prebiotics
Probiotics
Protein Science
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Summary:Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which has been reported to contribute to oral carcinogenesis. Therefore, in this review, we summarised the role of probiotics, prebiotics, synbiotics, and postbiotics in promoting a balanced oral microbiome, which may prevent oral carcinogenesis due to oral infections. Probiotics have been shown to produce biofilm, which possesses antibacterial activity against oral pathogens. Meanwhile, prebiotics can support growth and increase the benefit of probiotics. In addition, postbiotics possess antibacterial, anticariogenic, and anticancer properties that potentially aid in oral cancer prevention and treatment. The use of probiotics, prebiotics, synbiotics, and postbiotics for oral cancer management is still limited despite their vast potential, thus, discovering their prospects could herald a novel approach to disease prevention and treatment while participating in combating antimicrobial resistance.
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-022-09985-7