Ameliorating Effects of Bioactive Peptides Extracted from Litopenaeus vannamei Wastes on Oxidative Stress, Glucose Regulation, and Autophagy Gene Expression in Nonalcoholic Fatty Liver-Induced Rats

This study aimed to investigate the effect of bioactive peptides from Litopenaeus vannamei on oxidative stress, glucose regulation, and autophagy gene expression in the induced nonalcoholic fatty liver rats. Bioactive peptides used in the current study were extracted in a progressive rise in tempera...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022-08, Vol.2022, p.1-12
Main Authors: Moradian, Roya, Najdegerami, Ebrahim H., Nikoo, Mehdi, Nejati, Vahid
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Amino acids
Antioxidants
Autophagy
Body weight
By products
Cholesterol
Diet
Enzymes
Fatty liver
Gene expression
Glucose
Glycerol
Hepatocytes
High fat diet
Hypoglycemia
Insulin
Interleukin 6
Kinases
Litopenaeus vannamei
Liver diseases
Oxidative stress
Peptides
Phosphatase
Physiology
Plasma
Proteins
Tumor necrosis factor
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Summary:This study aimed to investigate the effect of bioactive peptides from Litopenaeus vannamei on oxidative stress, glucose regulation, and autophagy gene expression in the induced nonalcoholic fatty liver rats. Bioactive peptides used in the current study were extracted in a progressive rise in temperature (40–60°C) (GP). For this purpose, twenty-four healthy male rats (initial weight, 230.1 ± 22 g) were divided in four experimental groups including control (standard diet), HFD (high-fat diet), HFD + GP20, and 300 (high-fat diet + 20, 300 mg peptides/kg body weight). After 70 days, the results indicated that experimental treatments did not affect the body and liver weight (P>0.05), although the higher liver weight was seen in HFD treatment. Based on these results, the use of GP peptides improved antioxidant enzymes and decreased MDA concentration, and a significant difference was observed between peptide treatments and HFD (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/2679634