Lower pass threshold (≥93%) for critical congenital heart disease screening at high altitude prevents repeat screening and reduces false positives

Objective We evaluated first screen pass rate for two pass thresholds for critical congenital heart disease (CCHD) oxygen saturation (SpO 2 ) screening at higher altitude. Study design A retrospective cohort of 948 newborns underwent CCHD screening near sea-level ( n  = 463) vs 6250 ft altitude ( n...

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Bibliographic Details
Published in:Journal of perinatology 2022-09, Vol.42 (9), p.1176-1182
Main Authors: Sneeringer, M. Rhonda, Vadlaputi, Pranjali, Lakshminrusimha, Satyan, Siefkes, Heather
Format: Article
Language:English
Subjects:
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Algorithms
Altitude
Atmospheric pressure
Cardiovascular disease
Cardiovascular diseases
Cohort Studies
Congenital diseases
Coronary artery disease
Echocardiography
Heart
Heart Defects, Congenital - diagnosis
Heart diseases
High altitude
High-altitude environments
Hospitals
Humans
Infant, Newborn
Medical screening
Medicine
Medicine & Public Health
Neonatal Screening
Neonates
Oximetry
Oxygen
Oxygen content
Oxygen saturation
Pediatric Surgery
Pediatrics
Pulse oximetry
Retrospective Studies
Sea level
Ultrasonic imaging
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Summary:Objective We evaluated first screen pass rate for two pass thresholds for critical congenital heart disease (CCHD) oxygen saturation (SpO 2 ) screening at higher altitude. Study design A retrospective cohort of 948 newborns underwent CCHD screening near sea-level ( n  = 463) vs 6250 ft altitude ( n  = 485) over 3 years. Standard SpO 2 pass threshold ≥95% and lower SpO 2 pass threshold ≥93% (high-altitude screen) were applied to first measurements to compare pass frequencies. Results The median SpO 2 was lower in high-altitude newborns (96% vs 99%— p  
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-022-01491-6