The Regulation of miR-206 on BDNF: A Motor Function Restoration Mechanism Research on Cerebral Ischemia Rats by Meridian Massage

As a frequent disease affecting the nervous system, cerebral infarction has emerged as a major cause of disability and elicits disorders in motor, sensation, and cognition as sequelae. No clear mechanism has been known in meridian massage despite it having been proved to be an effective therapeutic...

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Published in:Evidence-based complementary and alternative medicine 2022-08, Vol.2022, p.1-11
Main Authors: Shi, Guofeng, Zeng, Ping, Zhao, Qing, Zhao, Jinju, Xie, Yunhui, Wen, Danguo, Yan, Lu, Gu, Hao, Ma, Shuai, Cai, Xiongwei
Format: Article
Language:English
Subjects:
Acupuncture
Alzheimer's disease
Animal cognition
Brain research
Brain-derived neurotrophic factor
Carotid arteries
Cerebral infarction
Chinese medicine
Cognition
Cognitive ability
Complications
Gastrocnemius muscle
Gene expression
Ischemia
Massage
Medical research
Musculoskeletal system
Myoblasts
Nervous system
Neurogenesis
Neurons
Physiology
Rehabilitation
Rodents
Sensation
Traditional Chinese medicine
Ultrastructure
Veins & arteries
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Summary:As a frequent disease affecting the nervous system, cerebral infarction has emerged as a major cause of disability and elicits disorders in motor, sensation, and cognition as sequelae. No clear mechanism has been known in meridian massage despite it having been proved to be an effective therapeutic option. The study was carried out to explore the treatment of meridian massage on cerebral ischemia in rats and its effects on motor function restoration and nerve cell’s ultrastructure in the ischemic territory. The alleviated nerve damages and recovered injured brain tissues were found in the cerebral infarction model of SD rats after meridian massage. Expressions of miR-206 and the brain-derived neurotrophic factor (BDNF) in the gastrocnemius muscle were all well observed. The effects of miR-206 on BDNF were testified by overexpressed and interfered miR-206 in the C2C12 myoblast. Moreover, at the molecular level, meridian massage downregulated miR-206 expression at an elevated level of BDNF. Consequently, meridian massage exerts a vital role in promoting cerebral ischemia restoration, which is expected to provide an addition to the application of traditional Chinese medicine (TCM) in the reconstruction and treatment of cerebral ischemia.
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/8172849