Altered Functional Connectivity in Pain-Related Brain Regions and Its Correlation with Pain Duration in Bone Metastasis with Cancer Pain

Bone metastatic pain is thought to be a severe type of cancer pain that has refractory characteristics and a long duration. This study is aimed at exploring the brain functional connectivity (FC) pattern in lung cancer patients with bone metastatic pain. In this study, 27 lung cancer patients with b...

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Bibliographic Details
Published in:Disease markers 2022, Vol.2022, p.3044186-9
Main Authors: Zhou, Xiaoyu, Tan, Yong, Chen, Jiao, Wang, Chengfang, Tang, Yu, Liu, Jiang, Lan, Xiaosong, Yu, Hong, Lai, Yong, Hu, Yixin, Zhang, Jing, Cao, Ying, Liu, Daihong, Zhang, Jiuquan
Format: Article
Language:English
Subjects:
Amygdala
Anxiety
Bone cancer
Bone Neoplasms - complications
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - pathology
Brain
Brain - diagnostic imaging
Brain mapping
Cancer Pain - diagnostic imaging
Cancer Pain - pathology
Connectivity analysis
Correlation analysis
Cortex (cingulate)
Cortex (somatosensory)
Data acquisition
Functional magnetic resonance imaging
Humans
Lung cancer
Lung Neoplasms - pathology
Magnetic Resonance Imaging
Medical imaging
Metastases
Metastasis
Neural networks
Neuroimaging
Pain
Pain - diagnostic imaging
Pain - etiology
Pain - pathology
Patients
Prefrontal cortex
Statistics
Thalamus
Variance analysis
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Summary:Bone metastatic pain is thought to be a severe type of cancer pain that has refractory characteristics and a long duration. This study is aimed at exploring the brain functional connectivity (FC) pattern in lung cancer patients with bone metastatic pain. In this study, 27 lung cancer patients with bone metastatic pain (CP+), 27 matched lung cancer patients without pain-related complaints (CP−), and 27 matched healthy controls (HC) were recruited. All participants underwent fMRI data acquisition and clinical assessments. One-way ANOVA or a Mann–Whitney U test was applied to compare clinical data according to data distribution. Seventeen hypothesis-driven pain-related brain regions were selected as regions of interest (ROIs). FC values among pain-related brain regions across the three groups were computed by using ROI–ROI functional connectivity analysis. ANCOVA with a post hoc test was applied to compare FC differences among the three groups. p
ISSN:0278-0240
1875-8630
1875-8630
DOI:10.1155/2022/3044186