Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi’s anemia

Fanconi’s anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrom...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2006-11, Vol.72 (6), p.845-848
Main Authors: Horta, Henrique de Lins e, Guimarães, Fernando Fernandes, Rocha, Luiz Otávio Savassi, Guimarães, Roberto Eustáquio Santos, Valadares, Eugênia Ribeiro
Format: Article
Language:English
Subjects:
Adult
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - radiotherapy
Case Report
Fanconi Anemia - complications
fanconi’s anemia
Fatal Outcome
Female
Humans
Hypopharynx
Pharyngeal Neoplasms - complications
Pharyngeal Neoplasms - diagnosis
Pharyngeal Neoplasms - radiotherapy
squamous cell carcinoma
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Summary:Fanconi’s anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrome, the treatment of such neoplasms is particularly difficult. In this paper we report the case of a 24-year-old woman with Fanconi’s anemia who developed a squamous cell carcinoma of the hypopharynx; she had none of the traditional risk factors, such as smoking and alcohol abuse. We also briefly review the literature about this topic
ISSN:1808-8694
1808-8686
DOI:10.1016/S1808-8694(15)31054-5