Research ethics in animal models

The use of animals in scientific experiments has beendescribed since the fifth century BC. A number of scientific advances in health are attributed to animal models. The issue of the moral status of animals has always been debated. This article aims to review and to present a historical summary of t...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2012-04, Vol.78 (2), p.128-131
Main Authors: Miziara, Ivan Dieb, de Matos Magalhães, Ana Tereza, Santos, Maruska d'Aparecida, Gomes, Érika Ferreira, de Oliveira, Reinaldo Ayer
Format: Article
Language:English
Subjects:
animal
Animal Experimentation - ethics
Animal Experimentation - legislation & jurisprudence
animal use alternatives
Animals
Bioethical Issues
Brazil
Dogs
ethics
ethics committees
Guinea Pigs
Mice
Models, Animal
Otolaryngology - ethics
Rabbits
Rats
Review
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Summary:The use of animals in scientific experiments has beendescribed since the fifth century BC. A number of scientific advances in health are attributed to animal models. The issue of the moral status of animals has always been debated. This article aims to review and to present a historical summary of the current laws, to guide researchers who wish to use animal models in otolaryngology research. Research on the medline database. For many years there were no laws ruling the use of animals in scientific experimentation in Brazil. Standards set by national and international organizations were followed. Recently, Law No. 11.794/08 established procedures for the scientific use of animals. Studies in otolaryngology have used the larynxes of rabbits, pigs, dogs, guinea pigs (Cavia porcellus), and mice. There were also studies comparing rabbits, rats, and dogs, rhinoplasty on rabbits, and inner ear studies on rats and guinea pigs (albino). The researchers involved in scientific work with animals should know the principles of Law 11.794/08 and investigate what animals are appropriate for each area of study in their models. Otolaryngologists, especially those dedicated to research, need to be mindful of the ethical rules regarding the use of animals in their studies.
ISSN:1808-8694
1808-8686
DOI:10.1590/S1808-86942012000200020